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A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon
- Source :
- Pathology internationalREFERENCES. 71(6)
- Publication Year :
- 2021
-
Abstract
- Lymphoepithelioma-like carcinoma is a poorly differentiated carcinoma with prominent lymphoid infiltration occurring in various organs but is exceedingly rare in the colorectal region. This malignancy is frequently associated with Epstein-Barr virus (EBV). Here we report a case of EBV-associated lymphoepithelioma-like carcinoma of the cecum in an 84-year-old male who presented with occult blood. In situ hybridization for EBV-encoded small RNAs (EBER) in an endoscopic submucosal dissection specimen showed that the tumor consisted of EBER-negative well-differentiated tubular adenocarcinoma and EBER-positive lymphoepithelioma-like carcinoma. Real-time PCR detected 7.16 copies of the EBV genome per cell in a sample microdissected from the latter component. Genotyping analysis demonstrated EBV genotype 1, and viral protein/transcript expression in the tumor showed EBV latency I. Expression of Ephrin receptor A2, a recently reported receptor for EBV, was demonstrated in the tumor cells by immunohistochemistry. To our knowledge, this is the first report of lymphoepithelioma-like carcinoma in the colorectal region showing a definite association with EBV infection.
- Subjects :
- 0301 basic medicine
Lymphoepithelioma-like carcinoma
Male
Pathology
medicine.medical_specialty
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Colorectal cancer
Colon
Biology
Adenocarcinoma
medicine.disease_cause
Malignancy
Virus
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Carcinoma
medicine
Humans
Colorectal Region
In Situ Hybridization
Aged, 80 and over
Receptor, EphA2
General Medicine
medicine.disease
Epstein–Barr virus
Immunohistochemistry
030104 developmental biology
030220 oncology & carcinogenesis
Tubular Adenocarcinoma
Colonic Neoplasms
Carcinoma, Squamous Cell
RNA, Viral
Subjects
Details
- ISSN :
- 14401827
- Volume :
- 71
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Pathology internationalREFERENCES
- Accession number :
- edsair.doi.dedup.....b91fb49769fb36cc91b19b5382594981