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Relationship Between Antihypertensive Medications and Cognitive Impairment: Part II. Review of Physiology and Animal Studies
- Source :
- Current Hypertension Reports
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are less clear. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews provide comprehensive review. Our extensive review includes 24 mechanistic animal and human studies published over the last 5 years assessing relationship between AHM and cognitive function. Recent Findings All classes of AHM showed similar result patterns in animal studies. The mechanism by which AHM exert their effect was extensively studied by evaluating well-established pathways of AD disease process, including amyloid beta (Aβ), vascular, oxidative stress and inflammation pathways, but only few studies evaluated the blood pressure lowering effect on the AD disease process. Summary Methodological limitations of the studies prevent comprehensive conclusions prior to further work evaluating AHM in animals and larger human observational studies, and selecting those with promising results for future RCTs.
- Subjects :
- 0301 basic medicine
Gerontology
Cognitive decline
Disease
Bioinformatics
Antihypertensive Agents: Mechanisms of Drug Action (M Ernst, Section Editor)
03 medical and health sciences
Cognition
0302 clinical medicine
Pharmacology And Pharmaceutical Sciences
Alzheimer Disease
Risk Factors
Internal Medicine
medicine
Animals
Humans
Dementia
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Antihypertensive Agents
Amyloid beta-Peptides
Antihypertensive medication
business.industry
medicine.disease
Disease Models, Animal
030104 developmental biology
Hypertension
Observational study
Animal studies
Alzheimer's disease
business
Alzheimer’s disease
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15343111 and 15226417
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Hypertension Reports
- Accession number :
- edsair.doi.dedup.....b915f4885e87a8e476f5f9a9cc539bbc