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Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma
- Source :
- World Journal of Gastroenterology. 14:1097
- Publication Year :
- 2008
- Publisher :
- Baishideng Publishing Group Inc., 2008.
-
Abstract
- AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma. METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005. RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology). CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings.
- Subjects :
- Male
medicine.medical_specialty
Biopsy
Cytodiagnosis
Malignancy
Sensitivity and Specificity
digestive system
Gastroenterology
Cholangiocarcinoma
Bile Ducts, Extrahepatic
hemic and lymphatic diseases
Internal medicine
Cytology
medicine
Humans
Endoscopy, Digestive System
neoplasms
Aged
Forceps biopsy
Cholangiopancreatography, Endoscopic Retrograde
Endoscopic retrograde cholangiopancreatography
medicine.diagnostic_test
business.industry
Brush cytology
Histology
General Medicine
respiratory system
Middle Aged
Surgical Instruments
medicine.disease
digestive system diseases
Endoscopy
Klatskin tumor
Bile Duct Neoplasms
Female
Radiology
business
Rapid Communication
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....b9150c292eb0c9a8745dcd5e1b1fbb78