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Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study
- Source :
- Brain and Mind Institute Researchers' Publications
- Publication Year :
- 2020
- Publisher :
- Scholarship@Western, 2020.
-
Abstract
- Given the emerging evidence in support of parietal brain stimulation to treat speech disorder in psychosis, we investigated structural and functional parietal dysconnectivity in schizophrenia (n = 34) and bipolar disorder with psychotic symptoms (n = 16). We found that both patient groups demonstrated reduced left parietal structural connectivity compared to healthy controls (n = 32). The three groups also differed significantly on the variability of left and right parietal dynamic functional connectivity. In patients with schizophrenia, parietal dysconnectivity predicted the severity of disorganisation symptoms. These findings suggest that dysconnectivity between the parietal lobe and the rest of the brain plays a key role in disorganisation symptoms of schizophrenia.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Bipolar Disorder
Neuroscience (miscellaneous)
Audiology
03 medical and health sciences
0302 clinical medicine
Parietal Lobe
medicine
Humans
Radiology, Nuclear Medicine and imaging
In patient
Bipolar disorder
Dynamic functional connectivity
Schizophrenia, Disorganized
business.industry
Structural connectivity
Parietal lobe
Middle Aged
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
Psychotic Disorders
Schizophrenia
Brain stimulation
Female
Speech disorder
Nerve Net
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Brain and Mind Institute Researchers' Publications
- Accession number :
- edsair.doi.dedup.....b9105d716485cdd988d4fc5f5af23d0d