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Metabolic syndrome in liver transplantation: A preoperative and postoperative concern
- Source :
- Surgery. 160(4)
- Publication Year :
- 2016
-
Abstract
- Background Metabolic syndrome is increasing among patients undergoing liver transplantation. Nonalcoholic steatohepatitis is a manifestation of metabolic syndrome and is an increasingly common cause of end-stage liver disease necessitating orthotopic liver transplantation. We sought to determine the effect of preoperative risk factors on the development of post-transplant metabolic syndrome, complications, readmissions, and mortality. Methods We conducted a review of 114 orthotopic liver transplantations at our institution from May 2012 to April 2014. Results Patients with (n = 19) and without (n = 95) metabolic syndrome were similar with regard to age, race, and model for end-stage liver disease at time of transplant. Donor and operative factors also were similar between the groups. Preoperative diabetes was found to be associated with an increased rate of readmission (odds ratio 3.45, P = .03). While preoperative metabolic syndrome itself was not a significant predictor of worse outcomes, postoperative metabolic syndrome was associated with significantly greater readmissions in the first year. Major predictors of new onset metabolic syndrome after orthotopic liver transplantation included preoperative diabetes and obesity (odds ratio 8.54 and odds ratio 5.49, P Conclusion Efforts to decrease the incidence of postoperative metabolic syndrome after orthotopic liver transplantation may decrease readmissions and improve outcomes, along with decreasing resource utilization.
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Databases, Factual
medicine.medical_treatment
030230 surgery
Liver transplantation
Risk Assessment
Severity of Illness Index
End Stage Liver Disease
03 medical and health sciences
Liver disease
0302 clinical medicine
Internal medicine
Diabetes mellitus
Severity of illness
Preoperative Care
medicine
Confidence Intervals
Odds Ratio
Humans
Survival rate
Aged
Retrospective Studies
Metabolic Syndrome
Postoperative Care
business.industry
Graft Survival
Retrospective cohort study
Odds ratio
Middle Aged
medicine.disease
Prognosis
Surgery
Liver Transplantation
Survival Rate
Treatment Outcome
Multivariate Analysis
030211 gastroenterology & hepatology
Female
Metabolic syndrome
business
Subjects
Details
- ISSN :
- 15327361
- Volume :
- 160
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Surgery
- Accession number :
- edsair.doi.dedup.....b90dc72a314bebc28833d798dbe738b3