Back to Search
Start Over
Malignancy and IgG4-related disease: the incidence, related factors and prognosis from a prospective cohort study in China
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in the Chinese cohort. We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical College Hospital from January 2011 to August 2018 and identified patients diagnosed with IgG4-RD complicating malignancies. Data regarding demographics, clinical features, treatment and prognosis of IgG4-RD patients complicating malignancies were collected and compared to those of age- and sex-matched controls. Among the 587 Chinese patients with IgG4-RD, 17 malignancies were identified. Ten of them developed malignancy after the diagnosis of IgG4-RD, given a standard incidence ratio (SIR) of 2.78 (95%CI 1.33–5.12). Multivariate logistic analysis indicated that autoimmune pancreatitis (OR = 6.230, 95%CI 1.559–24.907, p = 0.010) was positively associated with malignancy, whereas eosinophilia (OR = 0.094, 95%CI 0.010–0.883, p = 0.039) was negatively related with malignancies. During a median follow-up period of 61.4 ± 26.4 months, all patients with IgG4-RD and malignancies survived. We conclude that an increased incidence of malignancy was found in Chinese IgG4-RD cohort. Autoimmune pancreatitis is a potential risk factor, whereas eosinophilia is a possible protective factor for complicating malignancies.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
lcsh:Medicine
Disease
Malignancy
Article
Cohort Studies
03 medical and health sciences
Cancer epidemiology
0302 clinical medicine
Neoplasms
Internal medicine
parasitic diseases
medicine
Humans
Eosinophilia
Prospective cohort study
lcsh:Science
Aged
Autoimmune pancreatitis
030203 arthritis & rheumatology
Connective tissue diseases
Multidisciplinary
business.industry
Incidence
Incidence (epidemiology)
lcsh:R
Disease Management
Middle Aged
Prognosis
medicine.disease
Risk factors
Population Surveillance
Cohort
Female
030211 gastroenterology & hepatology
lcsh:Q
Disease Susceptibility
Immunoglobulin G4-Related Disease
medicine.symptom
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....b9098314df57272d4326455371263f63