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Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? : A small-scale longitudinal study
- Publication Year :
- 2019
- Publisher :
- Uppsala universitet, Klinisk fysiologi, 2019.
-
Abstract
- Aim: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6, and biomarkers of fetal iron status. Materials and methods: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth. Results: In T3, S-ferritin (median 14 mu g/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4.0 mg/L, i.e. within the reference interval. Median T3 S-hepcidin was 7.8 ng/mL. Later on in cord blood, ferritin concentration (180 mu g/L) were significantly higher, transferrin concentration (1.8 g/L) were significantly lower, and both sTfR (4.7 mg/L) and S-hepcidin concentrations (30.5 ng/mL) were significantly higher than maternal T3 concentrations. At the same time, cord blood interleukin-6 indicated an activated acute-phase reaction. In T3, after logarithmic transformation, there was a significant correlation between S-hepcidin and both S-ferritin (r = 0.691) and sTfR (r = -0.825). There was also a significant correlation between S-ferritin and both sTfR (r = -0.729) and transferrin (r = 0.549) in T3. Conclusions: Although S-ferritin, S-hepcidin, and sTfR were correlated during pregnancy, these relationships were not apparent in umbilical cord blood. Further, cord blood interleukin-6 indicated an activated acute-phase response, and sTfR, which is known to be unaffected by inflammation, indicated a low iron status in cord blood. Thus, instead of representing an enhanced iron status, the data appear to suggest that hepcidin and ferritin in cord blood may be influenced by the low-grade acute-phase response that occurs during delivery. Samtliga 3 författare delar förstaförfattarskapet.
- Subjects :
- inorganic chemicals
congenital, hereditary, and neonatal diseases and abnormalities
Longitudinal study
Pregnancy Trimester, Third
Iron
Physiology
digestive system
03 medical and health sciences
0302 clinical medicine
Hepcidins
Pregnancy
Hepcidin
hemic and lymphatic diseases
Receptors, Transferrin
Humans
Medicine
Longitudinal Studies
030212 general & internal medicine
Acute-Phase Reaction
Fetus
030219 obstetrics & reproductive medicine
biology
Interleukin-6
business.industry
ferritin
Parturition
Acute-phase protein
Klinisk medicin
nutritional and metabolic diseases
Obstetrics and Gynecology
Fetal Blood
medicine.disease
Late pregnancy
Ferritin
Cord blood
Ferritins
Pediatrics, Perinatology and Child Health
biology.protein
cord blood
Female
hepcidin
pregnancy
Clinical Medicine
business
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b9053f3ecf07386183d4b6a116b1e21d