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Yolk sac size & shape as predictors of first trimester pregnancy outcome: A prospective observational study
- Source :
- Journal of Gynecology Obstetrics and Human Reproduction. 48:159-164
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Objective To determine the value of yolk sac size and shape for prediction of pregnancy outcome in the first trimester. Material and methods 500 pregnant women between 6+0 and 9+6 weeks of gestation underwent transvaginal ultrasound and yolk sac diameter (YSD), gestational sac diameter (GSD) were measured, presence/absence of yolk sac (YS) and shape of the yolk sac were noted. Follow up ultrasound was done to confirm fetal well-being between 11+0 and 12+6 weeks and was the cutoff point of success of pregnancy. Results Out of 500 cases, 8 were lost to follow up, YS was absent in 14, of which 8 were anembryonic pregnancies. Thus, 478 out of 492 followed up cases were analyzed for YS shape and size and association with the pregnancy outcome. In our study, abnormal yolk sac shape had a sensitivity and specificity (87.06% & 86.5% respectively, positive predictive value (PPV) of 58.2%, negative predictive value (NPV) of 96.8% in predicting a poor pregnancy outcome as compared to yolk sac diameter (sensitivity and specificity 62.3% & 64.1% respectively and PPV and NPV of 27.3% and 88.7% respectively). The degree of association for both the variables was significant to the level of p Conclusion The presence or absence of yolk sac has a strong predictive value for poor pregnancy outcome. Yolk sac shape was a better predictor of poor pregnancy outcome in terms of higher specificity and negative predictive value as compared to yolk sac diameter.
- Subjects :
- Adult
medicine.medical_specialty
Gestational sac
Sensitivity and Specificity
Ultrasonography, Prenatal
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Prospective Studies
Yolk sac
Lost to follow-up
Yolk Sac
Gynecology
Fetus
030219 obstetrics & reproductive medicine
business.industry
Ultrasound
Pregnancy Outcome
Obstetrics and Gynecology
medicine.disease
Pregnancy Complications
Pregnancy Trimester, First
Transvaginal ultrasound
medicine.anatomical_structure
Reproductive Medicine
030220 oncology & carcinogenesis
embryonic structures
Gestation
Female
business
Subjects
Details
- ISSN :
- 24687847
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of Gynecology Obstetrics and Human Reproduction
- Accession number :
- edsair.doi.dedup.....b8fe91a9d29bd4008ae4d612a6b69600