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Double-blind Randomized Parallel Group Study Comparing the Efficacy and Safety of Tiotropium and Ipratropium in the Treatment of COPD Patients in Taiwan
- Source :
- Journal of the Formosan Medical Association, Vol 105, Iss 9, Pp 708-714 (2006)
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Background/PurposeTo compare the efficacy and safety of tiotropium and ipratropium in patients with chronic obstructive pulmonary disease (COPD) in Taiwan.MethodsThis double-blind, randomized, placebo-controlled, parallel group study was conducted at six hospitals in Taiwan. COPD patients aged ≥ 40 years, with a forced expiratory volume in 1 second (FEV1) ≤65% of predicted and FEV1/forced vital capacity (FVC) ≤ 70% were enrolled. After a 2-week screening/baseline period, 132 patients were randomized to receive 4 weeks of treatment with either tiotropium 18 μg once daily from a dry powder inhaler (HandiHaler(r)) or two puffs of ipratropium 20 μg four times daily from a metered dose inhaler. The primary outcome was the change in trough FEV1 from baseline to week 4. The secondary outcome measures were trough FVC response, FEV1 and FVC responses at 2 hours postinhalation.ResultsAfter 4 weeks, trough FEV1 had increased by 61.7 + 25.3 mL for tiotropium but decreased by 16.4 + 27.9 mL for ipratropium. The difference between groups was significant (p
- Subjects :
- Lung Diseases
Male
Vital capacity
Scopolamine Derivatives
Taiwan
Cholinergic Antagonists
law.invention
chronic obstructive pulmonary disease
Pulmonary Disease, Chronic Obstructive
FEV1/FVC ratio
Double-Blind Method
Randomized controlled trial
tiotropium
law
Atrial Fibrillation
Humans
Medicine
metered dose inhaler
Metered Dose Inhalers
Tiotropium Bromide
Aged
ipratropium
Aged, 80 and over
Medicine(all)
lcsh:R5-920
COPD
business.industry
General Medicine
Tiotropium bromide
Middle Aged
respiratory system
medicine.disease
Metered-dose inhaler
Dry-powder inhaler
Bronchodilator Agents
respiratory tract diseases
Treatment Outcome
Anesthesia
Ipratropium
Female
lcsh:Medicine (General)
business
HandiHaler
medicine.drug
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 09296646
- Volume :
- 105
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the Formosan Medical Association
- Accession number :
- edsair.doi.dedup.....b8f7969885049f6073f4419c8ae07b77
- Full Text :
- https://doi.org/10.1016/s0929-6646(09)60198-4