Back to Search
Start Over
Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states
- Source :
- Journal of Cerebral Blood Flow & Metabolism
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Understanding the neurovascular coupling (NVC) underlying hemodynamic changes in epilepsy is crucial to properly interpreting functional brain imaging signals associated with epileptic events. However, how excitatory and inhibitory neurons affect vascular responses in different epileptic states remains unknown. We conducted real-time in vivo measurements of cerebral blood flow (CBF), vessel diameter, and excitatory and inhibitory neuronal calcium signals during recurrent focal seizures. During preictal states, decreases in CBF and arteriole diameter were closely related to decreased γ-band local field potential (LFP) power, which was linked to relatively elevated excitatory and reduced inhibitory neuronal activity levels. Notably, this preictal condition was followed by a strengthened ictal event. In particular, the preictal inhibitory activity level was positively correlated with coherent oscillating activity specific to inhibitory neurons. In contrast, ictal states were characterized by elevated synchrony in excitatory neurons. Given these findings, we suggest that excitatory and inhibitory neurons differentially contribute to shaping the ictal and preictal neural states, respectively. Moreover, the preictal vascular activity, alongside with the γ-band, may reflect the relative levels of excitatory and inhibitory neuronal activity, and upcoming ictal activity. Our findings provide useful insights into how perfusion signals of different epileptic states are related in terms of NVC.
- Subjects :
- Male
neurovascular coupling
cerebral blood flow
Neuroimaging
Local field potential
Inhibitory postsynaptic potential
Mice
03 medical and health sciences
Epilepsy
0302 clinical medicine
Calcium imaging
Seizures
excitatory neuron
inhibitory neuron
medicine
Animals
Premovement neuronal activity
Ictal
030304 developmental biology
Neurons
Photons
0303 health sciences
Chemistry
Hemodynamics
Original Articles
medicine.disease
Electrophysiology
Mice, Inbred C57BL
Arterioles
calcium imaging
nervous system
Neurology
Cerebral blood flow
Cerebrovascular Circulation
Models, Animal
Excitatory postsynaptic potential
in vivo two-photon imaging
Calcium
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15597016 and 0271678X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....b8f53a1802669561f7bb66346ffbb2d3
- Full Text :
- https://doi.org/10.1177/0271678x20934071