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Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
- Source :
- Nature. 371(6499)
- Publication Year :
- 1994
-
Abstract
- Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
- Subjects :
- Basic fibroblast growth factor
Molecular Sequence Data
Palatine Tonsil
Mice, Nude
Biology
Virus
Cell Line
Pathogenesis
Extracellular matrix
chemistry.chemical_compound
Mice
medicine
Extracellular
Cell Adhesion
Animals
Humans
Collagenases
Receptor
Kaposi's sarcoma
Sarcoma, Kaposi
Skin
Acquired Immunodeficiency Syndrome
Extracellular Matrix Proteins
Mice, Inbred BALB C
Multidisciplinary
Base Sequence
Molecular Mimicry
virus diseases
medicine.disease
Virology
Fibronectins
Enzyme Activation
chemistry
Matrix Metalloproteinase 9
Gene Products, tat
Collagenase
Cancer research
HIV-1
Fibroblast Growth Factor 2
tat Gene Products, Human Immunodeficiency Virus
medicine.drug
Subjects
Details
- ISSN :
- 00280836
- Volume :
- 371
- Issue :
- 6499
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....b8f44127d23ed159657d91aaf163ad04