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Schizophyllum commune: an emergent or misdiagnosed fungal pathogen in rhinology?

Authors :
Renaud Piarroux
Carole Boulze
Anne Cécile Normand
Stéphane Ranque
Justin Michel
Patrick Dessi
Danièle Maubon
Christian Righini
Damien Arthur Varoquaux
Hôpital de la Timone [CHU - APHM] (TIMONE)
Aix Marseille Université (AMU)
CHU Grenoble
Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble
Université Grenoble Alpes (UGA)
Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques (IP-TPT)
Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Service de Santé des Armées
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE)
Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48
Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)
Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES)
Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Institut de Biologie et Pathologie
Clinique ORL, Pôle Tête et cou et Chirurgie Réparatrice
Université Joseph Fourier - Grenoble 1 (UJF)
INSB-INSB-Centre National de la Recherche Scientifique (CNRS)
Source :
Medical Mycology, Medical Mycology, 2016, 54 (3), pp.301-309. ⟨10.1093/mmy/myv084⟩, Medical Mycology, Oxford University Press, 2016, 54 (3), pp.301-309. ⟨10.1093/mmy/myv084⟩
Publication Year :
2016
Publisher :
HAL CCSD, 2016.

Abstract

International audience; Schizophyllum commune is a common basidiomycete fungus that is rarely involved in human disease. The medical records of patients operated on for fungal rhinosinusitis (FRS) in two University Hospitals between 2012 and 2014 were reviewed. Within the two-year survey, six female, and notably no male, patients were diagnosed with S. commune rhinosinusitis. Mean age was 44.6 years at diagnosis (30 to 68 years). Mean time between onset of symptoms and diagnosis was 8.5 months (2 to 12 months). All six patients were immunocompetent and had no particular host factor for FRS. S. commune was identified using MALDI-TOF mass spectrometry and identifications were confirmed via DNA sequence analysis. Chronic invasive fungal rhinosinusitis was diagnosed in three of our six patients. Based on histological findings, antifungal treatment was delivered in association with surgery. The basidiomycete fungus S. commune is an emerging cause of rhinosinusitis probably as a direct consequence of the recent technological progress in fungal identificationmethods (DNA sequencing and MALDI-TOF mass spectrometry).

Details

Language :
English
ISSN :
13693786 and 1365280X
Database :
OpenAIRE
Journal :
Medical Mycology, Medical Mycology, 2016, 54 (3), pp.301-309. ⟨10.1093/mmy/myv084⟩, Medical Mycology, Oxford University Press, 2016, 54 (3), pp.301-309. ⟨10.1093/mmy/myv084⟩
Accession number :
edsair.doi.dedup.....b8da23fe852fff6f07f46a545fd0bb7c