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Granulocyte-Colony Stimulating Factor and Erythropoietin Therapy in Children with Human Immunodeficiency Virus Infection
- Source :
- Scopus-Elsevier
- Publication Year :
- 1996
- Publisher :
- SAGE Publications, 1996.
-
Abstract
- To determine whether granulocyte-colony stimulating factor and erythropoietin are effective in the therapy of neutropenia and anaemia related to human immunodeficiency virus (HIV) infection and to anti-retroviral agents, we recruited 11 HIV-infected children (mean age 4 years 10 months). All the children were given granulocyte-colony stimulating factor at a dosage of 5 μ-g/kg twice or three times a week while erythropoietin was administered additionally to three patients at a dosage of 50 U/kg twice a week. Both agents were administered subcutaneously for at least 4 months. Leukocyte and neutrophil counts significantly increased during the treatment (after 1 month, P = 0.003 and P = 0.009, respectively). Erythropoietin prevented blood transfusions and increased haemoglobin levels in the three children treated. No side-effects were recorded during the administration of either agent. Granulocyte-colony stimulating factor and erythropoietin appear to be safe and useful agents in the management of HIV-infected children.
- Subjects :
- Male
medicine.medical_specialty
Neutrophils
Anemia
medicine.medical_treatment
HIV Infections
030204 cardiovascular system & hematology
Neutropenia
Antiviral Agents
Biochemistry
Gastroenterology
Leukocyte Count
03 medical and health sciences
0302 clinical medicine
Internal medicine
Immunopathology
Granulocyte Colony-Stimulating Factor
medicine
Humans
Child
Sida
Erythropoietin
Chemotherapy
Leukopenia
biology
business.industry
Biochemistry (medical)
Infant
Drug Tolerance
Cell Biology
General Medicine
medicine.disease
biology.organism_classification
Granulocyte colony-stimulating factor
Child, Preschool
030220 oncology & carcinogenesis
Immunology
Drug Therapy, Combination
Female
medicine.symptom
business
Zidovudine
medicine.drug
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....b8d68b06509022d81a8c329bc9df938d
- Full Text :
- https://doi.org/10.1177/030006059602400115