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Granulocyte-Colony Stimulating Factor and Erythropoietin Therapy in Children with Human Immunodeficiency Virus Infection

Authors :
Elisabetta Riva
Giacomo Biasucci
M Clerici-Schoeller
Giuseppe Banderali
S. Decarlis
Gian Vincenzo Zuccotti
Anna Plebani
R Startari
Source :
Scopus-Elsevier
Publication Year :
1996
Publisher :
SAGE Publications, 1996.

Abstract

To determine whether granulocyte-colony stimulating factor and erythropoietin are effective in the therapy of neutropenia and anaemia related to human immunodeficiency virus (HIV) infection and to anti-retroviral agents, we recruited 11 HIV-infected children (mean age 4 years 10 months). All the children were given granulocyte-colony stimulating factor at a dosage of 5 μ-g/kg twice or three times a week while erythropoietin was administered additionally to three patients at a dosage of 50 U/kg twice a week. Both agents were administered subcutaneously for at least 4 months. Leukocyte and neutrophil counts significantly increased during the treatment (after 1 month, P = 0.003 and P = 0.009, respectively). Erythropoietin prevented blood transfusions and increased haemoglobin levels in the three children treated. No side-effects were recorded during the administration of either agent. Granulocyte-colony stimulating factor and erythropoietin appear to be safe and useful agents in the management of HIV-infected children.

Details

ISSN :
14732300 and 03000605
Volume :
24
Database :
OpenAIRE
Journal :
Journal of International Medical Research
Accession number :
edsair.doi.dedup.....b8d68b06509022d81a8c329bc9df938d
Full Text :
https://doi.org/10.1177/030006059602400115