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Subcortical Aphasia
- Source :
- Stroke. 36:1467-1473
- Publication Year :
- 2005
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2005.
-
Abstract
- Background and Purpose— Very few neuroimaging studies have focused on follow-up of subcortical aphasia. Here, overt language production tasks were used to correlate regional cerebral blood flow (rCBF) changes and language performance in patients with vascular subcortical lesions. Methods— Seven aphasic patients were scanned twice with positron emission tomography (PET) at 1-year interval during a word-generation task. Using SPM2, Language-Rest contrast at PET1 was correlated to language performance and to time-lag from stroke. The same contrast was performed at PET2 and session effect (PET2–PET1) was correlated with performance improvement. Results— At PET1, correlation between rCBF and delay from stroke involved mainly ventral regions of the left temporal cortex and mesial frontal cortex. Correlations between rCBF and performance showed predominantly left dorsal regions in the frontal, temporal, and parietal lobes, but also the left ventral temporal cortex. One year apart, language performance improved and rCBF increased in perisylvian regions bilaterally. Best performers at PET2 showed an increase of activity in left ventral temporal cortex as well as in right middle temporal gyrus. Conclusions— On follow-up, expected language improvement and increase of activation in the classical language areas and their counterparts were observed. Moreover, all correlational analyses both at PET1 and on follow-up implicated the anterior part of the left inferior temporal gyrus, suggesting a disconnection between the superior and inferior parts of the left temporal cortex and a specific role for this region in lexical semantic processing.
- Subjects :
- Adult
Male
medicine.medical_specialty
Audiology
Brain mapping
Aphasia, Wernicke
Neuroimaging
Communication disorder
Aphasia
medicine
Humans
Temporal dynamics of music and language
Semantic memory
Language disorder
Longitudinal Studies
Aged
Language
Advanced and Specialized Nursing
Temporal cortex
Aphasia, Broca
Brain Mapping
business.industry
Brain
Middle Aged
medicine.disease
Temporal Lobe
Frontal Lobe
Surgery
Stroke
Treatment Outcome
nervous system
Cerebrovascular Circulation
Positron-Emission Tomography
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
psychological phenomena and processes
Subjects
Details
- ISSN :
- 15244628 and 00392499
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....b8c4671668b2a94d83efbff375f17572