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ISCEV extended protocol for the dark-adapted red flash ERG
- Source :
- Documenta Ophthalmologica. Advances in Ophthalmology
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the dark-adapted (DA) red flash ERG. The DA red flash ERG can be incorporated conveniently within the ISCEV standard ERG protocol after a minimum of 20-min DA and recorded after the DA 0.01 ERG to a flash strength of 0.3 phot cd s m−2, eliciting a waveform with two positive peaks in healthy individuals. The first positive component is the cone-mediated x-wave with a peak at 30–50 ms; the second is a rod-mediated b-wave with a peak time of approximately 100 ms. Shorter DA times may be desirable to shorten the recording time or to alter the prominence of the early cone-mediated x-wave relative to the rod-mediated b-wave. The DA red flash ERG is used to aid the diagnosis of achromatopsia (rod monochromacy), cone dystrophy and other forms of cone system dysfunction, including “Bradyopsia” (RGS9/R9AP-retinopathy), when the DA red flash ERG x-wave is preserved in the absence of ISCEV standard LA ERGs. The DA red flash ERG can also help determine the origin of residual DA ERGs in cases of severe rod dysfunction, for example in disorders such as vitamin A deficiency, fundus albipunctatus (RDH5-retinopathy), Oguchi disease (SAG- or GRK1-retinopathy) and some rod-cone dystrophies. To shorter DA periods, the x-wave may be elicited without the following rod b-wave, shown to be helpful in abbreviated protocols for children.
- Subjects :
- Adult
Male
medicine.medical_specialty
Achromatopsia
Clinical standards
genetic structures
Electroretinogram (ERG)
ISCEV Standards
Dark Adaptation
03 medical and health sciences
Flash (photography)
0302 clinical medicine
Clinical Protocols
Cone dystrophy
Physiology (medical)
Ophthalmology
Retinal Dystrophies
Electroretinography
International Society of Clinical Electrophysiology of Vision (ISCEV)
Dark-adapted (DA)
medicine
Humans
030212 general & internal medicine
Child
Societies, Medical
medicine.diagnostic_test
Vitamin A Deficiency
Red flash ERG
business.industry
Oguchi disease
Retinal dystrophy
BRADYOPSIA
medicine.disease
eye diseases
Sensory Systems
Electrophysiology
Dark-adapted
Retinal Cone Photoreceptor Cells
030221 ophthalmology & optometry
Female
sense organs
business
Erg
Photic Stimulation
Full-field ERG
Subjects
Details
- ISSN :
- 15732622 and 00124486
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Documenta Ophthalmologica
- Accession number :
- edsair.doi.dedup.....b8c34c92664d356a175ab0fbfc95c32d