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Supplementary Tables S1 - S5, Figures S1 - S5 from A Large Multiethnic Genome-Wide Association Study of Prostate Cancer Identifies Novel Risk Variants and Substantial Ethnic Differences

Authors :
John S. Witte
Neil Risch
Catherine Schaefer
Pui-Yan Kwok
Mark N. Kvale
Daniela Seminara
Brian E. Henderson
Christopher A. Haiman
Lorelei A. Mucci
Kathryn L. Penney
Matthew L. Freedman
Qiyuan Li
Stephen N. Thibodeau
Daniel J. Schaid
Amy J. French
Shannon K. McDonnell
Stephen J. Chanock
Sonja I. Berndt
Zhaoming Wang
Joseph Presti
David Aaronson
Charles P. Quesenberry
Dilrini K. Ranatunga
Jun Shan
Nirupa R. Ghai
Chun R. Chao
Nima C. Emami
Clinton L. Cario
Michael N. Passarelli
Rebecca E. Graff
Laurel A. Habel
Eric Jorgenson
Lori C. Sakoda
Stephen K. Van Den Eeden
Thomas J. Hoffmann
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Table S1. Descriptive factors for KP study population, broken down by study. Supplementary Table S2. Genome-wide significant SNPs found in our cohort. Supplementary Table S3. Cis-eQTL expression of rs4646284. Supplementary Table S4. Results at the 105 loci previously found to be associated with prostate cancer. Supplementary Table S5. Risk score of and variance explained by the 105 previously reported hits. Supplementary Figure S1. Manhattan and Q-Q plots of each race/ethnicity and meta-analysis. Supplementary Figure S2. Local plots of novel replicated rs4646284 and suggestive rs2659124. Supplementary Figure S3. Cis-eQTL of SLC22A1 and SLC22A3. Supplementary Figure S4. Comparison of ORs of KP to previous reports by race/ethnicity. Supplementary Figure S5. KP AUC estimates.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....b8b2bff2d8c86df2754f6553c7b45ff9
Full Text :
https://doi.org/10.1158/2159-8290.22531545