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The establishment of Neisseria meningitidis serogroup W135 of the clonal complex ET-37/ST-11 as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso
- Source :
- Microbes and Infection. 7:645-649
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- We analyzed 48 invasive isolates of Neisseria meningitidis that were isolated from meningitis cases in Burkina Faso (April 2002 to April 2003). Thirty-nine of these isolates had the phenotype (serogroup:serotype:serosubtype) W135:2a:P1.5,2, eight isolates were A:4:P1.9 and one isolate was nongroupable:nonserotypable:nonserosubtypable. Genotyping of meningococcal isolates showed that W135 isolates belonged to the sequence type (ST)-11. The nongroupable isolate was of genogroup W135 and belonged to ST-192. Isolates of serogroup A belonged to ST-2859 (a member of the subgroup III/ST-5 clonal complex). W135 (ST-11) isolates involved in meningitis outbreaks in Burkina Faso differed from those involved in the Hajj-2000 associated outbreak by their pulsed-field gel electrophoresis profile. These data confirm the changing epidemiology of meningococcal infection in Burkina Faso with the establishment and expansion of serogroup W135 N. meningitidis strains of the ET-37/ST-11 clonal complex, as well as the emergence of a new clone within the subgroup III/ST-5 clonal complex.
- Subjects :
- Male
Serotype
Adolescent
Genotype
Immunology
Meningitis, Meningococcal
medicine.disease_cause
Communicable Diseases, Emerging
Microbiology
Neisseria meningitidis, Serogroup W-135
Burkina Faso
parasitic diseases
medicine
Humans
Prospective Studies
Child
Genotyping
Molecular Epidemiology
biology
Molecular epidemiology
Neisseria meningitidis
Infant
Outbreak
biology.organism_classification
Virology
Bacterial Typing Techniques
Phenotype
Infectious Diseases
Child, Preschool
Population Surveillance
Multilocus sequence typing
Female
Neisseriaceae
Subjects
Details
- ISSN :
- 12864579
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Microbes and Infection
- Accession number :
- edsair.doi.dedup.....b8a48c6c5afa2553c91f0817c5ab82bb