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Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles
- Source :
- Bioorganic & Medicinal Chemistry Letters. 19:1517-1521
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.
- Subjects :
- Indoles
Pyridines
Antiparasitic
medicine.drug_class
Stereochemistry
Clinical Biochemistry
Substituent
Pharmaceutical Science
Biochemistry
Poultry
chemistry.chemical_compound
In vivo
Drug Discovery
Cyclic GMP-Dependent Protein Kinases
medicine
Animals
Potency
Molecular Biology
Indole test
Coccidiosis
Chemistry
Organic Chemistry
Biological activity
Combinatorial chemistry
In vitro
Coccidiostats
Molecular Medicine
Amine gas treating
Eimeria tenella
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....b89d716eae661d5308a05e327f2850b7
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.01.001