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Regorafenib-to-trifluridine/tipiracil Versus the Reverse Sequence for Refractory Metastatic Colorectal Cancer Patients: A Multicenter Retrospective Real-life Experience
- Source :
- Anticancer Research. 41:2553-2561
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background/aim Regorafenib (REG) and trifluridine/tipiracil (FTD/TPI) have have been shown to improve overall survival in patients with refractory metastatic colorectal cancer. The aim of our study was to evaluate the efficacy and safety profiles of these agents administered in sequence in real world practice. Patients and methods Clinical data of patients treated beyond the 2°line with REG or FTD/TPI between January 2016 and August 2020, were retrospectively collected from eight institutes in the Lazio Region. Results We included 49 patients treated with both drug sequences. A total of 28 G3/G4 toxicity events (53.8%) were recorded in the FTD/TPI-to-REG sequence vs. 24 (46.1%) in the reverse sequence. Median overall survival for the patients included in the FTP/TPI-to-REG group was 20 months (95%CI=16.7-23.3) vs. 27 months in the reverse group (95%CI=17.8-36.2). The disease control rate was 45.0% for patients treated with the REG-to-FTD/TPI sequence vs. 24.1% in those treated with the FTD/TPI-to-REG sequence (p=0.18). Conclusion The sequence REG-to-FTD/TPI and vice versa can extend survival, whereas only REG-to-FTD/TPI stabilizes cancer growth.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Pyrrolidines
Pyridines
Colorectal cancer
Trifluridine
Kaplan-Meier Estimate
Drug Administration Schedule
chemistry.chemical_compound
Refractory
Regorafenib
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
mental disorders
parasitic diseases
medicine
Humans
Neoplasm Metastasis
Aged
Tipiracil
Sequence (medicine)
Aged, 80 and over
business.industry
Phenylurea Compounds
Cancer
General Medicine
Middle Aged
medicine.disease
Progression-Free Survival
Lazio region
chemistry
Female
Colorectal Neoplasms
business
Thymine
medicine.drug
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....b89cd6a6b448f9d761b09c7d32e5e5be