Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals

Authors :: Aditya Sankar
Faizaan Mohammad
Arun Kumar Sundaramurthy
Hua Wang
Mads Lerdrup
Tulin Tatar
Kristian Helin
Source :: Nat Genet
Publication Year :: 2022
Publisher :: Springer Science and Business Media LLC, 2022.
Abstract: A new study employs CRISPR/Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability for H3K27ac in transcriptional activation.

Subjects :: Histones
Mammals
Mice
Drosophila melanogaster
Polycomb Repressive Complex 2
Genetics
Animals
Acetylation
Methylation
Protein Processing, Post-Translational
Chromatin
Article

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