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Sequential Production of Birbeck Granules Through Adsorptive Pinocytosis
- Source :
- Journal of Investigative Dermatology. 82:28-29
- Publication Year :
- 1984
- Publisher :
- Elsevier BV, 1984.
-
Abstract
- A case of vitiligo with inflammatory raised borders was observed electron microsocopically, resulting in an interesting view of the formation of Birbeck granules in Langerhans cells. Following the formation of larger coated vesicles, which perform adsorptive pinocytosis from the cell membrane, membrane invagination of the cell occurred shown as the tubular infolding, resulting in the observation of the characteristic Birbeck granule band pattern in its interior. This phenomenon supports the theory of Hashimoto and Tarnowski (1968) that Birbeck granules are formed from the infolding of the cell membrane. In addition, our study shows the involvement of adsorptive pinocytosis in the formation of the granules. It was suggested that when the coated Birbeck granule shifts into the cell, possibly its coat is detached and the vesicle portion forms the globule of the Birbeck granule.
- Subjects :
- Adult
Birbeck granules
Cell
Vitiligo
Coated vesicle
Dermatology
Cytoplasmic Granules
Biochemistry
Cell membrane
medicine
Humans
Band pattern
Molecular Biology
Membrane invagination
integumentary system
Chemistry
Pinocytosis
Vesicle
Cell Membrane
Cell Biology
Anatomy
Microscopy, Electron
medicine.anatomical_structure
Langerhans Cells
Biophysics
Female
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....b885b5eaf6c50e561c02668849a23599