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Adenosine stress perfusion cardiac magnetic resonance imaging in patients undergoing intracoronary bone marrow cell transfer after ST-elevation myocardial infarction: the BOOST-2 perfusion substudy
- Source :
- Clinical Research in Cardiology. 109:539-548
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- In the placebo-controlled, double-blind BOne marrOw transfer to enhance ST-elevation infarct regeneration (BOOST) 2 trial, intracoronary autologous bone marrow cell (BMC) transfer did not improve recovery of left ventricular ejection fraction (LVEF) at 6 months in patients with ST-elevation myocardial infarction (STEMI) and moderately reduced LVEF. Regional myocardial perfusion as determined by adenosine stress perfusion cardiac magnetic resonance imaging (S-CMR) may be more sensitive than global LVEF in detecting BMC treatment effects. Here, we sought to evaluate (i) the changes of myocardial perfusion in the infarct area over time (ii) the effects of BMC therapy on infarct perfusion, and (iii) the relation of infarct perfusion to LVEF recovery at 6 months. In 51 patients from BOOST-2 (placebo, n = 10; BMC, n = 41), S-CMR was performed 5.1 ± 2.9 days after PCI (before placebo/BMC treatment) and after 6 months. Infarct perfusion improved from baseline to 6 months in the overall patient cohort as reflected by the semi-quantitative parameters, perfusion defect–infarct size ratio (change from 0.54 ± 0.20 to 0.43 ± 0.22; P = 0.006) and perfusion defect–upslope ratio (0.54 ± 0.23 to 0.68 ± 0.22; P
- Subjects :
- Male
medicine.medical_specialty
Adenosine
Vasodilator Agents
030204 cardiovascular system & hematology
Placebo
Sensitivity and Specificity
Cohort Studies
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Double-Blind Method
Cardiac magnetic resonance imaging
Internal medicine
Humans
Medicine
cardiovascular diseases
030212 general & internal medicine
Myocardial infarction
Aged
Bone Marrow Transplantation
Ejection fraction
Ventricular Remodeling
medicine.diagnostic_test
business.industry
Area under the curve
Stroke Volume
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Treatment Outcome
medicine.anatomical_structure
Conventional PCI
cardiovascular system
Cardiology
ST Elevation Myocardial Infarction
Female
Bone marrow
Cardiology and Cardiovascular Medicine
business
Perfusion
Subjects
Details
- ISSN :
- 18610692 and 18610684
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Clinical Research in Cardiology
- Accession number :
- edsair.doi.dedup.....b878c3560d9dd0888c4ed949e1a2b818