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Selective Human Serum Albumin Sensor from the Screening of a Fluorescent Rosamine Library
- Source :
- Journal of Combinatorial Chemistry. 10:376-380
- Publication Year :
- 2008
- Publisher :
- American Chemical Society (ACS), 2008.
-
Abstract
- A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with approximately 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.
- Subjects :
- Serum albumin
Biosensing Techniques
Sensitivity and Specificity
Fluorescence
Small Molecule Libraries
Species Specificity
medicine
Animals
Combinatorial Chemistry Techniques
Humans
Serum Albumin
Fluorescent Dyes
Chromatography
Molecular Structure
biology
Chemistry
Extramural
Serum Albumin, Bovine
Stereoisomerism
General Chemistry
Human serum albumin
Highly selective
Highly sensitive
body regions
Fluorescence intensity
Biochemistry
biology.protein
Cattle
medicine.drug
Macromolecule
Subjects
Details
- ISSN :
- 15204774 and 15204766
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Combinatorial Chemistry
- Accession number :
- edsair.doi.dedup.....b876f7a510028cd8e01d507e753108f3