Back to Search
Start Over
Heritability of the Effective Connectivity in the Resting-State Default Mode Network
- Source :
- Cerebral cortex (New York, N.Y. : 1991). 27(12)
- Publication Year :
- 2015
-
Abstract
- The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity. Model comparison favored a full-connected model. Structural equal modeling was used to estimate the additive genetics (A), common environment (C) and unique environment (E) contributions to variance for the DMN effective connectivity. The ACE model was preferred in the comparison of structural equation models. Heritability of DMN effective connectivity was 0.54, suggesting that the genetic made a greater contribution to the effective connectivity within DMN. Establishing the heritability of default-mode effective connectivity endorses the use of resting-state networks as endophenotypes or intermediate phenotypes in the search for the genetic basis of psychiatric or neurological illnesses.
- Subjects :
- 0301 basic medicine
Male
Adolescent
Cognitive Neuroscience
Rest
Inheritance Patterns
Cognitive neuroscience
Biology
Structural equation modeling
03 medical and health sciences
Cellular and Molecular Neuroscience
Neural activity
Young Adult
0302 clinical medicine
Neural Pathways
Twins, Dizygotic
Humans
Default mode network
Causal model
Brain Mapping
Models, Statistical
Resting state fMRI
Models, Genetic
Brain
Twins, Monozygotic
Heritability
Magnetic Resonance Imaging
030104 developmental biology
Endophenotype
Female
Gene-Environment Interaction
human activities
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14602199
- Volume :
- 27
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Accession number :
- edsair.doi.dedup.....b870e824e88e6c44f7d964ff9aa2fa6f