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Acute effects of very-low-protein diet on FGF23 levels: a randomized study
- Source :
- Clinical journal of the American Society of Nephrology : CJASN. 7(4)
- Publication Year :
- 2012
-
Abstract
- Summary Background and objectives High levels of fibroblast growth factor 23 are associated with mortality, CKD progression, and calcification in CKD patients. The aim of this pilot study is to assess whether a very-low-protein diet (0.3 g/kg per day) with a consequent low intake of phosphorus would reduce fibroblast growth factor 23 compared with a low-protein diet (0.6 g/kg per day) in CKD patients not yet on dialysis. Design, setting, participants, & measurements A prospective, randomized, controlled crossover study was performed in which 32 patients were randomized into two groups. Group A (16 patients) received a very-low-protein diet (0.3 g/kg body wt per day) supplemented with ketoanalogues during the first week and a low-protein diet during the second week, and group B (16 patients) received a low-protein diet during the first week and a very-low-protein diet during the second week. Fibroblast growth factor 23, seric, and urinary phosphate levels were measured at baseline and the end of each study period. Results After only 1 week of the very-low-protein diet, reductions in fibroblast growth factor 23 levels (33.5%), serum phosphate (12%), and urinary phosphate (34%) with the very-low-protein diet compared with the low-protein diet were observed. Serum and urinary phosphate levels and protein intake were significant determinants of fibroblast growth factor 23 (95% confidence interval=1.04–1.19, 1.12–1.37, and 1.51–2.23, respectively). Conclusions A very-low-protein diet supplemented with ketoanalogues reduced fibroblast growth factor 23 levels in CKD patients not yet on dialysis.
- Subjects :
- Fibroblast growth factor 23
Male
medicine.medical_specialty
Time Factors
Epidemiology
very-low-protein diet, ketoanalogues , fibroblast growth factor 23, CKD patients
medicine.medical_treatment
Urinary system
Down-Regulation
Pilot Projects
Critical Care and Intensive Care Medicine
Gastroenterology
law.invention
Low-protein diet
Randomized controlled trial
law
Internal medicine
Diet, Protein-Restricted
Odds Ratio
Medicine
Humans
Prospective Studies
Prospective cohort study
Dialysis
Aged
Transplantation
Cross-Over Studies
business.industry
Odds ratio
Middle Aged
Crossover study
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Endocrinology
Treatment Outcome
Italy
Nephrology
Chronic Disease
Multivariate Analysis
Phosphorus, Dietary
Regression Analysis
Female
Kidney Diseases
business
Biomarkers
Subjects
Details
- ISSN :
- 1555905X
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical journal of the American Society of Nephrology : CJASN
- Accession number :
- edsair.doi.dedup.....b86351376e99bf04b1eadae5bc59b1a8