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New genetic loci link adipose and insulin biology to body fat distribution
Authors :
Shungin, Dmitry Winkler, Thomas W Workalemahu, Tsegaselassie Hartman, Catharina A Duncan, Emma L Ntzani, Evangelia E Oei, Ling Albagha, Omar M E Amin, Najaf Kemp, John P Koller, Daniel L Li, Guo Liu, Ching-Ti Minster, Ryan L Hassinen, Maija Moayyeri, Alireza Vandenput, Liesbeth Willner, Dana Xiao, Su-Mei Yerges-Armstrong, Laura M Zheng, Hou-Feng Alonso, Nerea Eriksson, Joel Kammerer, Candace M Kaptoge, Stephen K Hayward, Caroline Leo, Paul J Thorleifsson, Gudmar Wilson, Scott G Wilson, James F Aalto, Ville Alen, Markku Aragaki, Aaron K Aspelund, Thor Center, Jacqueline R Dailiana, Zoe Heikkilä, Kauko Duggan, David J Garcia, Melissa Garcia-Giralt, Natàlia Giroux, Sylvie Hallmans, Göran Hocking, Lynne J Husted, Lise Bjerre Jameson, Karen A Khusainova, Rita Kim, Ghi Su Herzig, Karl-Heinz Kooperberg, Charles Koromila, Theodora Kruk, Marcin Laaksonen, Marika Lacroix, Andrea Z Lee, Seung Hun Leung, Ping C Lewis, Joshua R Masi, Laura Mencej-Bedrac, Simona Helmer, Quinta Nguyen, Tuan V Nogues, Xavier Patel, Millan S Prezelj, Janez Rose, Lynda M Scollen, Serena Siggeirsdottir, Kristin Smith, Albert V Svensson, Olle Trompet, Stella Hillege, Hans L Trummer, Olivia van Schoor, Natasja M Woo, Jean Zhu, Kun Balcells, Susana Brandi, Maria Luisa Buckley, Brendan M Cheng, Sulin Christiansen, Claus Cooper, Cyrus Holmen, Oddgeir Dedoussis, George Ford, Ian Frost, Morten Goltzman, David González-Macías, Jesús Kähönen, Mika Karlsson, Magnus Khusnutdinova, Elza Koh, Jung-Min Kollia, Panagoula Hunt, Steven C Langdahl, Bente Lomholt Leslie, William D Lips, Paul Ljunggren, Östen Lorenc, Roman S Marc, Janja Mellström, Dan Obermayer-Pietsch, Barbara Olmos, José M Pettersson-Kymmer, Ulrika Isaacs, Aaron Reid, David M Riancho, José A Ridker, Paul M Rousseau, François Slagboom, P Eline Tang, Nelson L S Urreizti, Roser Van Hul, Wim Viikari, Jorma Zarrabeitia, María T Wu, Joseph M W Ittermann, Till Aulchenko, Yurii S Castano-Betancourt, Martha Grundberg, Elin Herrera, Lizbeth Ingvarsson, Thorvaldur Johannsdottir, Hrefna Kwan, Tony Li, Rui Luben, Robert Medina-Gómez, Carolina James, Alan L Palsson, Stefan Th Reppe, Sjur Rotter, Jerome I Sigurdsson, Gunnar van Meurs, Joyce B J Verlaan, Dominique Williams, Frances M K Wood, Andrew R Zhou, Yanhua Gautvik, Kaare M Johansson, Ingegerd Pastinen, Tomi Raychaudhuri, Soumya Cauley, Jane A Chasman, Daniel I Clark, Graeme R Cummings, Steven R Danoy, Patrick Dennison, Elaine M Eastell, Richard Eisman, John A Juliusdottir, Thorhildur Gudnason, Vilmundur Hofman, Albert Jackson, Rebecca D Jones, Graeme Jukema, J Wouter Khaw, Kay-Tee Lehtimäki, Terho Liu, Yongmei Lorentzon, Mattias McCloskey, Eugene Kalafati, Ioanna-Panagiota Mitchell, Braxton D Nandakumar, Kannabiran Nicholson, Geoffrey C Oostra, Ben A Peacock, Munro Pols, Huibert A P Prince, Richard L Raitakari, Olli Reid, Ian R Robbins, John Kinnunen, Leena Sambrook, Philip N Sham, Pak Chung Shuldiner, Alan R Tylavsky, Frances A van Duijn, Cornelia M Wareham, Nick J Cupples, L Adrienne Econs, Michael J Evans, David M Harris, Tamara B Koenig, Wolfgang Kung, Annie Wai Chee Psaty, Bruce M Reeve, Jonathan Spector, Timothy D Streeten, Elizabeth A Zillikens, M Carola Thorsteinsdottir, Unnur Ohlsson, Claes Karasik, David Richards, J Brent Kooner, Ishminder K Brown, Matthew A Stefansson, Kari Uitterlinden, André G Ralston, Stuart H Ioannidis, John P A Kiel, Douglas P Rivadeneira, Fernando Sandholm, Niina Salem, Rany M McKnight, Amy Jayne Kratzer, Wolfgang Brennan, Eoin P Forsblom, Carol Isakova, Tamara McKay, Gareth J Williams, Winfred W Sadlier, Denise M Mäkinen, Ville-Petteri Swan, Elizabeth J Palmer, Cameron Boright, Andrew P Lamina, Claudia Ahlqvist, Emma Deshmukh, Harshal A Keller, Benjamin J Huang, Huateng Ahola, Aila Fagerholm, Emma Gordin, Daniel Harjutsalo, Valma He, Bing Heikkilä, Outi Buchkovich, Martin L Leander, Karin Hietala, Kustaa Kytö, Janne Lahermo, Päivi Lehto, Markku Österholm, Anne-May Parkkonen, Maija Pitkäniemi, Janne Rosengård-Bärlund, Milla Saraheimo, Markku Sarti, Cinzia Lee, Nanette R Söderlund, Jenny Soro-Paavonen, Aino Syreeni, Anna Thorn, Lena M Tikkanen, Heikki Tolonen, Nina Tryggvason, Karl Tuomilehto, Jaakko Wadén, Johan Gill, Geoffrey V Lichtner, Peter Prior, Sarah Guiducci, Candace Mirel, Daniel B Taylor, Andrew Hosseini, Mohsen Parving, Hans-Henrik Rossing, Peter Tarnow, Lise Ladenvall, Claes Alhenc-Gelas, François Lind, Lars Lefebvre, Pierre Rigalleau, Vincent Roussel, Ronan Tregouet, David-Alexandre Maestroni, Anna Maestroni, Silvia Falhammar, Henrik Gu, Tianwei Möllsten, Anna Cimponeriu, Dan Lindström, Jaana Mihai, Ioana Mota, Maria Mota, Eugen Serafinceanu, Cristian Stavarachi, Monica Hanson, Robert L Nelson, Robert G Kretzler, Matthias Colhoun, Helen M Panduru, Nicolae Mircea Lobbens, Stéphane Gu, Harvest F Brismar, Kerstin Zerbini, Gianpaolo Hadjadj, Samy Marre, Michel Groop, Leif Lajer, Maria Bull, Shelley B Waggott, Daryl Paterson, Andrew D Savage, David A Bain, Stephen C Martin, Finian Hirschhorn, Joel N Godson, Catherine Florez, Jose C Groop, Per-Henrik Maxwell, Alexander P Willer, Cristen J Schmidt, Ellen M Mach, François Sengupta, Sebanti Peloso, Gina M Gustafsson, Stefan Kanoni, Stavroula Ganna, Andrea Chen, Jin Mora, Samia Beckmann, Jacques S Bragg-Gresham, Jennifer L Magnusson, Patrik Ke Chang, Hsing-Yi Demirkan, Ayşe Den Hertog, Heleen M Do, Ron Donnelly, Louise A Ehret, Georg B Esko, Tõnu Feitosa, Mary F Ferreira, Teresa Fischer, Krista Mahajan, Anubha Fontanillas, Pierre Fraser, Ross M Freitag, Daniel F Gurdasani, Deepti Hyppönen, Elina Jackson, Anne U Johansson, Åsa Johnson, Toby Heard-Costa, Nancy L McArdle, Wendy L Kaakinen, Marika Kettunen, Johannes Kleber, Marcus E Li, Xiaohui Luan, Jian'an Lyytikäinen, Leo-Pekka Magnusson, Patrik K E Mangino, Massimo Mihailov, Evelin Montasser, May E Menni, Cristina Müller-Nurasyid, Martina Nolte, Ilja M O'Connell, Jeffrey R Palmer, Cameron D Perola, Markus Petersen, Ann-Kristin Sanna, Serena Saxena, Richa Service, Susan K Shah, Sonia Merger, Sigrun Sidore, Carlo Song, Ci Strawbridge, Rona J Surakka, Ida Tanaka, Toshiko Teslovich, Tanya M Van den Herik, Evita G Voight, Benjamin F Volcik, Kelly A Waite, Lindsay L Wong, Andrew Wu, Ying Zhang, Weihua Absher, Devin Asiki, Gershim Barroso, Inês Been, Latonya F Bolton, Jennifer L Milani, Lili Bonnycastle, Lori L Brambilla, Paolo Burnett, Mary S Cesana, Giancarlo Dimitriou, Maria Doney, Alex S F Döring, Angela Elliott, Paul Epstein, Stephen E Eyjolfsson, Gudmundur Ingi Mills, Rebecca Gigante, Bruna Goodarzi, Mark O Grallert, Harald Gravito, Martha L Groves, Christopher J Hartikainen, Anna-Liisa Hernandez, Dena Hicks, Andrew A Holm, Hilma Hung, Yi-Jen Illig, Thomas Jones, Michelle R Kaleebu, Pontiano Kastelein, John J P Kim, Eric Klopp, Norman Komulainen, Pirjo Monda, Keri L Kumari, Meena Langenberg, Claudia Lin, Shih-Yi Loos, Ruth J F Meisinger, Christa Mooijaart, Simon P Müller, Gabrielle Nagaraja, Ramaiah Narisu, Narisu Nieminen, Tuomo V M Nsubuga, Rebecca N Olafsson, Isleifur Ong, Ken K Palotie, Aarno Papamarkou, Theodore Pomilla, Cristina Mühleisen, Thomas W Pouta, Anneli Rader, Daniel J Reilly, Muredach P Rudan, Igor Ruokonen, Aimo Samani, Nilesh Scharnagl, Hubert Seeley, Janet Roman, Tamara S Mulas, Antonella Silander, Kaisa Stančáková, Alena Stirrups, Kathleen Swift, Amy J Tiret, Laurence Uitterlinden, Andre G van Pelt, L Joost Vedantam, Sailaja Wainwright, Nicholas Wijmenga, Cisca Müller, Gabriele Wild, Sarah H Willemsen, Gonneke Wilsgaard, Tom Young, Elizabeth H Zhao, Jing Hua Adair, Linda S Arveiler, Dominique Assimes, Themistocles L Bandinelli, Stefania Bennett, Franklyn Bochud, Murielle Boehm, Bernhard O Boomsma, Dorret I Borecki, Ingrid B Bornstein, Stefan R Bovet, Pascal Burnier, Michel Campbell, Harry Chakravarti, Aravinda Chambers, John C Chen, Yii-Der Ida Collins, Francis S Cooper, Richard S Danesh, John de Faire, Ulf Feranil, Alan B Ferrières, Jean Ferrucci, Luigi Nalls, Michael A Freimer, Nelson B Gieger, Christian Groop, Leif C Gyllensten, Ulf Hamsten, Anders Hingorani, Aroon Hovingh, G Kees Hsiung, Chao Agnes Humphries, Steve E Hveem, Kristian Iribarren, Carlos Järvelin, Marjo-Riitta Jula, Antti Kaprio, Jaakko Glorioso, Nicola Kesäniemi, Antero Kivimaki, Mika Kooner, Jaspal S Koudstaal, Peter J Krauss, Ronald M Kuh, Diana Kuusisto, Johanna Kyvik, Kirsten O Laakso, Markku Lakka, Timo A Lindgren, Cecilia M Martin, Nicholas G März, Winfried McCarthy, Mark I McKenzie, Colin A Meneton, Pierre Metspalu, Andres Moilanen, Leena Morris, Andrew D Olden, Matthias Munroe, Patricia B Njølstad, Inger Pedersen, Nancy L Power, Chris Pramstaller, Peter P Price, Jackie F Quertermous, Thomas Rauramaa, Rainer Saleheen, Danish Rayner, Nigel W Salomaa, Veikko Sanghera, Dharambir K Saramies, Jouko Schwarz, Peter E H Sheu, Wayne H-H Siegbahn, Agneta Spector, Tim D Strachan, David P Drong, Alexander W Renstrom, Frida Tayo, Bamidele O Tremoli, Elena Uusitupa, Matti Vollenweider, Peter Wallentin, Lars Wareham, Nicholas J Whitfield, John B Wolffenbuttel, Bruce H R Ried, Janina S Ordovas, Jose M Boerwinkle, Eric Palmer, Colin N A Franks, Paul W Ripatti, Samuli Sandhu, Manjinder S Robertson, Neil R Rich, Stephen S Boehnke, Michael Deloukas, Panos Kathiresan, Sekar Mohlke, Karen L Ingelsson, Erik Abecasis, Gonçalo R Abecasis, Gonçalo Caulfield, Mark Chasman, Dan Ehret, Georg Johnson, Andrew Johnson, Louise Larson, Martin Levy, Daniel Munroe, Patricia Newton-Cheh, Christopher O'Reilly, Paul Palmas, Walter Psaty, Bruce Rice, Kenneth Smith, Albert Snider, Harold Tobin, Martin Van Duijn, Cornelia Verwoert, Germaine Rice, Kenneth M Johnson, Andrew D Tobin, Martin D Verwoert, Germaine C Hwang, Shih-Jen Pihur, Vasyl Scholtens, Salome O'Reilly, Paul F Teumer, Alexander Glazer, Nicole L Launer, Lenore Aulchenko, Yurii Heath, Simon Sennblad, Bengt Sõber, Siim Parsa, Afshin Arora, Pankaj Dehghan, Abbas Zhang, Feng Lucas, Gavin Peden, John F Seufferlein, Thomas Igl, Wilmar Milaneschi, Yuri Parker, Alex N Fava, Cristiano Fox, Ervin R Sitlani, Colleen M Go, Min Jin van der Harst, Pim Kao, Wen Hong Linda Sjögren, Marketa Vinay, D. G. Alexander, Myriam Tabara, Yasuharu Shaw-Hawkins, Sue Whincup, Peter H Smith, Albert Vernon Shi, Gang Tayo, Bamidele Seielstad, Mark Sim, Xueling Nguyen, Khanh-Dung Hoang Matullo, Giuseppe Gaunt, Tom R Onland-Moret, N Charlotte Cooper, Matthew N Platou, Carl G P Org, Elin Hardy, Rebecca Dahgam, Santosh Palmen, Jutta Vitart, Veronique Braund, Peter S Kuznetsova, Tatiana Stringham, Heather M Uiterwaal, Cuno S P M Adeyemo, Adebowale Ludwig, Barbara Tomaszewski, Maciej Tzoulaki, Ioanna Palmer, Nicholette D Sundström, Johan Chang, Yen-Pei C Steinle, Nanette I Grobbee, Diederick E Arking, Dan E Kardia, Sharon L Morrison, Alanna C Najjar, Samer Swertz, Morris A Hadley, David Brown, Morris J Connell, John M Hingorani, Aroon D Day, Ian N M Lawlor, Debbie A Beilby, John P Lawrence, Robert W Clarke, Robert Collins, Rory Hopewell, Jemma C Ongen, Halit Dreisbach, Albert W Li, Yali Young, J. H. Bis, Joshua C Syvänen, Ann-Christine Chen, Ming-Huei Pattaro, Cristian Bolton, Judith A Hoffman Köttgen, Anna Bergmann, Sven Mooser, Vincent Chaturvedi, Nish Frayling, Timothy M Islam, Muhammad Jafar, Tazeen H Erdmann, Jeanette Kulkarni, Smita R Grässler, Jürgen Howard, Philip Thorand, Barbara Guarrera, Simonetta Ricceri, Fulvio Emilsson, Valur Plump, Andrew Weder, Alan B Sun, Yan V Bergman, Richard N Scott, Laura J Peltonen, Leena Vartiainen, Erkki Brand, Stefan-Martin Staessen, Jan A Wang, Thomas J Tomaschitz, Andreas Burton, Paul R Artigas, Maria Soler Dong, Yanbin Snieder, Harold Wang, Xiaoling Zhu, Haidong Lohman, Kurt K Rudock, Megan E Heckbert, Susan R Smith, Nicholas L Troffa, Chiara Wiggins, Kerri L Doumatey, Ayo Shriner, Daniel Veldre, Gudrun Viigimaa, Margus Kinra, Sanjay Prabhakaran, Dorairajan Tripathy, Vikal Langefeld, Carl D Rosengren, Annika van Oort, Floor Va Thelle, Dag S Corsi, Anna Maria Singleton, Andrew Forrester, Terrence Hilton, Gina Salako, Tunde Iwai, Naoharu Kita, Yoshikuni Ogihara, Toshio Verweij, Niek Ohkubo, Takayoshi Okamura, Tomonori Ueshima, Hirotsugu Umemura, Satoshi Eyheramendy, Susana Meitinger, Thomas Wichmann, H-Erich Cho, Yoon Shin Kim, Hyung-Lae Lee, Jong-Young Vonk, Judith M Scott, James Sehmi, Joban S Hedblad, Bo Nilsson, Peter Smith, George Davey Stanèáková, Alena Raffel, Leslie J Yao, Jie O'Donnell, Chris Schwartz, Stephen M Ikram, M Arfan Longstreth, W. T. Mosley, Thomas H Seshadri, Sudha Shrine, Nick R G Wain, Louise V Wennauer, Roman Morken, Mario A Laitinen, Jaana Prokopenko, Inga Zitting, Paavo Cooper, Jackie A Rasheed, Asif Goel, Anuj Watkins, Hugh Bakker, Stephan J L van Gilst, Wiek H Janipalli, Charles S Mani, K Radha Yajnik, Chittaranjan S Mattace-Raso, Francesco U S Wojczynski, Mary K Demirkan, Ayse Lakatta, Edward G Orru, Marco Scuteri, Angelo Ala-Korpela, Mika Kangas, Antti J Soininen, Pasi Tukiainen, Taru Würtz, Peter Ong, Rick Twee-Hee Dörr, Marcus Kroemer, Heyo K Völker, Uwe Völzke, Henry Galan, Pilar Hercberg, Serge Lathrop, Mark Day, Felix R Zhang, Qunyuan Zelenika, Diana Zhai, Guangju Meschia, James F Sharma, Pankaj Terzic, Janos Kumar, M J Kranthi Denniff, Matthew Zukowska-Szczechowska, Ewa Wagenknecht, Lynne E Fowkes, F Gerald R Charchar, Fadi J Guo, Xiuqing Rotimi, Charles Bots, Michiel L Brand, Eva Samani, Nilesh J Polasek, Ozren Talmud, Philippa J Nyberg, Fredrik Laan, Maris Palmer, Lyle J van der Schouw, Yvonne T Choi, Murim Casas, Juan P Vineis, Paolo Ganesh, Santhi K Wong, Tien Y Tai, E Shyong Rao, Dabeeru C Eriksson, Per Morris, Richard W Dominiczak, Anna F Marmot, Michael G Miki, Tetsuro Chandak, Giriraj R Coresh, Josef Navis, Gerjan Folkersen, Lasse Han, Bok-Ghee Zhu, Xiaofeng Melander, Olle Gyllensten, Ulf B Wright, Alan F Franco-Cereceda, Anders Farrall, Martin Elosua, Roberto Soranzo, Nicole Sijbrands, Eric J G Altshuler, David Gharavi, Ali G Rettig, Rainer Uda, Manuela Witteman, Jacqueline C M Hedman, Åsa K Vasan, Ramachandran S Larson, Martin G Hivert, Marie-France Caulfield, Mark J Anderson, Carl A Gordon, Scott D Guo, Qun Henders, Anjali K Esko, Tonu Huang, Jinyan Lambert, Ann Lee, Sang Hong Kraft, Peter Kennedy, Stephen H Macgregor, Stuart Missmer, Stacey A Montgomery, Grant W Morris, Andrew P Nyholt, Dale R Painter, Jodie N Roseman, Fenella Treloar, Susan A Visscher, Peter M Wallace, Leanne Zondervan, Krina T Alizadeh, Behrooz Z de Boer, Rudolf A Boezen, H Marike Bruinenberg, Marcel Karpe, Fredrik Franke, Lude van der Klauw, Melanie M Ormel, Johan Postma, Dirkje S Rosmalen, Judith G M Slaets, Joris P Keildson, Sarah Stolk, Ronald P Scott, Robert A Lagou, Vasiliki Welch, Ryan P Wheeler, Eleanor Mägi, Reedik Kiryluk, Krzysztof Rehnberg, Emil Rasmussen-Torvik, Laura J Yengo, Loïc Lecoeur, Cecile Liang, Liming Johnson, Paul C D Hottenga, Jouke-Jan Lifton, Richard P Salo, Perttu Timpson, Nicholas J St Pourcain, Beate Andrews, Jeanette S Hui, Jennie Bielak, Lawrence F Ma, Baoshan Zhao, Wei Horikoshi, Momoko Navarro, Pau Esko, Tönu McKnight, Amy J Fall, Tove Chen, Han Robertson, Neil Rybin, Denis McPherson, Ruth Willems, Sara M Chines, Peter S Kang, Hyun Min Song, Kijoung Croteau-Chonka, Damien C An, Ping Marullo, Letizia Jansen, Hanneke Oldehinkel, Albertine J Min, Josine L Pankow, James S North, Kari E Forouhi, Nita G Edkins, Sarah Varga, Tibor V Oksa, Heikki Antonella, Mulas Moffatt, Miriam F Kong, Augustine Herder, Christian Antti, Jula Small, Kerrin 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Christopher E Meduri, Eshwar di Meglio, Paola Montgomery, Stephen B Nestle, Frank O Nica, Alexandra C Nisbet, James O'Rahilly, Stephen Parts, Leopold Potter, Simon Sekowska, Magdalena Shin, So-Youn Consortium, ADIPOGen Small, Kerrin S Surdulescu, Gabriela Travers, Mary E Tsaprouni, Loukia Tsoka, Sophia Wilk, Alicja Yang, Tsun-Po Consortium, CARDIOGRAMplusC4D Matise, Tara Buyske, Steve Higashio, Julia Williams, Rasheeda Nato, Andrew Ambite, Jose Luis Deelman, Ewa Manolio, Teri Hindorff, Lucia Consortium, CKDGen Heiss, Gerardo Taylor, Kira Franceschini, Nora Avery, Christy Graff, Misa Lin, Danyu Quibrera, Miguel Cochran, Barbara Kao, Linda Umans, Jason Consortium, GEFOS Cole, Shelley MacCluer, Jean Person, Sharina Pankow, James Gross, Myron Fornage, Myriam Durda, Peter Jenny, Nancy Patsy, Bruce Consortium, GENIE Arnold, Alice Buzkova, Petra Crawford, Dana Haines, Jonathan Murdock, Deborah Glenn, Kim Brown-Gentry, Kristin Thornton-Wells, Tricia Dumitrescu, Logan Jeff, Janina GLGC Bush, William S Mitchell, Sabrina L Goodloe, Robert Wilson, Sarah Boston, Jonathan Malinowski, Jennifer Restrepo, Nicole Oetjens, Matthew Fowke, Jay Zheng, Wei ICBP Spencer, Kylee Ritchie, Marylyn Pendergrass, Sarah Le Marchand, Loïc Wilkens, Lynne Park, Lani Tiirikainen, Maarit Kolonel, Laurence Lim, Unhee Cheng, Iona Consortium, International Endogene Wang, Hansong Shohet, Ralph Haiman, Christopher Stram, Daniel Henderson, Brian Monroe, Kristine Schumacher, Fredrick Peters, Ulrike Anderson, Garnet Study, LifeLines Cohort Carlson, Chris Prentice, Ross LaCroix, Andrea Wu, Chunyuan Carty, Cara Gong, Jian Rosse, Stephanie Young, Alicia Haessler, Jeff Kocarnik, Jonathan Investigators, MAGIC Lin, Yi Jackson, Rebecca Duggan, David Kuller, Lew Perry, John R B He, Chunyan Sulem, Patrick Consortium, MuTHER Barbalic, Maja Broer, Linda Byrne, Enda M Ernst, Florian Gudbjartsson, Daniel F McArdle, Patick F Consortium, PAGE Porcu, Eleonora van Wingerden, Sophie Zhuang, Wei V Albrecht, Eva Randall, Joshua C Consortium, ReproGen Lauc, Lovorka Barac Boban, Mladen Broekmans, Frank J Burri, Andrea Chanock, Stephen J Chen, Constance Cornelis, Marilyn C Amouyel, Philippe Corre, Tanguy Coviello, Andrea D d'Adamo, Pio Davies, Gail Deary, Ian J Dedoussis, George V Z Deloukas, Panagiotis Ebrahim, Shah Eiriksdottir, Gudny Eriksson, Johan G Fauser, Bart C J M Ferreli, Liana Folsom, Aaron R Garcia, Melissa E Gasparini, Paolo Bakker, Stephan Jl Glazer, Nicole Hall, Per Haller, Toomas Hankinson, Susan E Hass, Merli Heath, Andrew C Beilby, John Janssens, A Cecile J W Kardia, Sharon L R Keyzer, Jules Kolcic, Ivana Lahti, Jari Lai, Sandra Laisk, Triin Laven, Joop S E Liu, Jianjun Lopez, Lorna M Louwers, Yvonne V Marongiu, Mara Blangero, John Klaric, Irena Martinovic Masciullo, Corrado McKnight, Barbara Medland, Sarah E Melzer, David Newman, Anne B Paré, Guillaume Peeters, Petra H M Pistis, Giorgio Plump, Andrew S Pop, Victor J M Räikkönen, Katri Sala, Cinzia Salumets, Andres Smith, Jennifer A Stacey, 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O Li, Shengxu Melbye, Mads Murray, Jeffrey C Murray, Sarah S Nelis, Mari Ness, Andrew R Northstone, Kate Franco, Oscar H Pennell, Craig E Pharoah, Paul Rafnar, Thorunn Rice, John P Ring, Susan M Gansevoort, Ron T Schork, Nicholas J Segrè, Ayellet V Sovio, Ulla Srinivasan, Sathanur R Tammesoo, Mar-Liis Tikkanen, Emmi Tyrer, Jonathon van Meurs, Joyve B J Waeber, Gerard Weedon, Michael N Haiman, Christopher A Young, Lauren Zhuang, Wei Vivian Bierut, Laura J Boyd, Heather A Hattersley, Andrew T Schreiber, Stefan Heliövaara, Markku Hoffmann, Wolfgang Homuth, Georg Johansen, Berit Jousilahti, Pekka Jula, Antti M Kee, Frank Fehrmann, Rudolf Kraja, Aldi T Kuulasmaa, Kari Le Marchand, Loic Karjalainen, Juha Lyssenko, Valeriya Männistö, Satu Marette, André Matise, Tara C Musk, Arthur W Möhlenkamp, Stefan Kahali, Bratati Raitakari, Olli T Rankinen, Tuomo Rao, D. C. 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Verwoert, G. Rice, KM. Tobin, MD. Verwoert, GC. Pihur, V. O'Reilly, PF. Launer, L. Aulchenko, Y. Heath, S. Sõber, S. Arora, P. Zhang, F. Lucas, G. Milaneschi, Y. Parker, AN. Fava, C. Fox, ER. Go, MJ. Sjögren, M. Vinay, D. Alexander, M. Tabara, Y. Shaw-Hawkins, S. Whincup, PH. Shi, G. Tayo, B. Seielstad, M. Sim, X. Nguyen, KD. Matullo, G. Gaunt, TR. Onland-Moret, NC. Cooper, MN. Platou, CG. Org, E. Hardy, R. Dahgam, S. Palmen, J. Kuznetsova, T. Uiterwaal, CS. Adeyemo, A. Ludwig, B. Tomaszewski, M. Tzoulaki, I. Palmer, ND. Chang, YP. Steinle, NI. Grobbee, DE. Morrison, AC. Najjar, S. Hadley, D. Brown, MJ. Connell, JM. Hingorani, AD. Day, IN. Lawlor, DA. Beilby, JP. Lawrence, RW. Ongen, H. Li, Y. Young, JH. Bis, JC. Lee, NR. Bolton, JA. Chaturvedi, N. Islam, M. Jafar, TH. Kulkarni, SR. Grässler, J. Howard, P. Guarrera, S. Ricceri, F. Emilsson, V. Plump, A. Weder, AB. Sun, YV. Bergman, RN. Scott, LJ. Stringham, HM. Peltonen, L. Vartiainen, E. Brand, SM. Staessen, JA. Wang, TJ. Burton, PR. Artigas, MS. Dong, Y. Snieder, H. Wang, X. Zhu, H. Lohman, KK. Rudock, ME. Heckbert, SR. Smith, NL. Wiggins, KL. Doumatey, A. Shriner, D. Veldre, G. Viigimaa, M. Kinra, S. Prabhakaran, D. Tripathy, V. Langefeld, CD. Rosengren, A. Thelle, DS. Corsi, AM. Singleton, A. Forrester, T. Hilton, G. Salako, T. Iwai, N. Kita, Y. Ogihara, T. Ohkubo, T. Okamura, T. Ueshima, H. Umemura, S. Eyheramendy, S. Meitinger, T. Cho, YS. Kim, HL. Scott, J. Sehmi, JS. Hedblad, B. Nilsson, P. Stanèáková, A. Raffel, LJ. Yao, J. Schwartz, SM. Ikram, M. Longstreth W.<Suffix>Jr</Suffix> Mosley, TH. Seshadri, S. Shrine, NR. Wain, LV. Morken, MA. Laitinen, J. Zitting, P. Cooper, JA. van Gilst WH. Janipalli, CS. Mani, K. Yajnik, CS. Mattace-Raso, FU. Lakatta, EG. Orru, M. Scuteri, A. Ala-Korpela, M. Kangas, AJ. Soininen, P. Tukiainen, T. Würtz, P. Ong, RT. Dörr, M. Galan, P. Hercberg, S. Lathrop, M. Zelenika, D. Zhai, G. Meschia, JF. Nalls, MA. Sharma, P. Terzic, J. Kumar, M. Denniff, M. Zukowska-Szczechowska, E. Wagenknecht, LE. Fowkes, F. Charchar, FJ. Rotimi, C. Bots, ML. Brand, E. Talmud, PJ. Nyberg, F. Laan, M. Palmer, LJ. van der Schouw YT. Casas, JP. Vineis, P. Ganesh, SK. Wong, TY. Tai, ES. Rao, DC. Morris, RW. Dominiczak, AF. Marmot, MG. Miki, T. Chandak, GR. Zhu, X. Gyllensten, UB. Elosua, R. Soranzo, N. Sijbrands, EJ. Uda, M. Vasan, RS. Larson, MG. Caulfield, MJ. Anderson, CA. Gordon, S. Guo, Q. Henders, A. Lambert, A. Kraft, P. Kennedy, SH. Macgregor, S. Missmer, SA. Montgomery, GW. Nyholt, DR. Painter, JN. Roseman, F. Treloar, SA. Visscher, PM. Wallace, L. Zondervan, KT. Alizadeh, B. de Boer RA. Boezen, HM. Bruinenberg, M. Franke, L. Hillege, HL. van der Klauw MM. Ormel, J. Postma, DS. Rosmalen, JG. Slaets, JP. Stolk, RP. Lagou, V. Welch, RP. Wheeler, E. Rehnberg, E. Yengo£££Loïc£££ L. Lecoeur, C. Johnson, PC. Mahajan, A. Verweij, N. Hottenga, JJ. Sennblad, B. Salo, P. Timpson, NJ. Hui, J. Bielak, LF. Zhao, W. Horikoshi, M. Navarro, P. Esko, T. Fall, T. Chen, H. Robertson, N. Rybin, D. Chines, PS. Song, K. An, P. Marullo, L. Jansen, H. Oldehinkel, AJ. North, KE. Forouhi, NG. Edkins, S. Varga, TV. Oksa, H. Antonella, M. Kong, A. Herder, C. Antti, J. Miljkovic, I. Atalay, M. Kiess, W. James, AL. Smit, JH. Campbell, S. Fowkes, GR. Basart, HV. Rathmann, W. Maerz, W. Province, MA. Watanabe, RM. de Geus EJ. Penninx, BW. Oostra, B. Toenjes, A. Peyser, PA. Körner, A. Keinanen-Kiukaanniemi, SM. Saaristo, TE. Boomsma, D. Cucca, F. Balkau, B. Froguel, P. Jarvelin, MR. Bouatia-Naji, N. Ahmadi, KR. Ainali, C. Barrett, A. Bataille, V. Bell, JT. Buil, A. Dermitzakis, ET. Dimas, AS. Durbin, R. Glass, D. Hassanali, N. Hedman£££Åsa K£££ ÅK. Ingle, C. Keildson, S. Knowles, D. Krestyaninova, M. Lowe, CE. Meduri, E. di Meglio, P. Min, JL. Montgomery, SB. Nestle, FO. Nica, AC. Nisbet, J. O'Rahilly, S. Parts, L. Potter, S. Sekowska, M. Shin, SY. Small, KS. Surdulescu, G. Travers, ME. Tsaprouni, L. Tsoka, S. Wilk, A. Matise, T. Buyske, S. Higashio, J. Williams, R. Nato, A. Ambite, JL. Deelman, E. Manolio, T. Hindorff, L. Heiss, G. Taylor, K. Avery, C. Graff, M. Lin, D. Quibrera, M. Cochran, B. Kao, L. Umans, J. Cole, S. MacCluer, J. Person, S. Pankow, J. Gross, M. Fornage, M. Durda, P. Jenny, N. Patsy, B. Arnold, A. Buzkova, P. Crawford, D. Haines, J. Murdock, D. Glenn, K. Brown-Gentry, K. Thornton-Wells, T. Dumitrescu, L. Jeff, J. Bush, WS. Mitchell, SL. Goodloe, R. Wilson, S. Boston, J. Malinowski, J. Restrepo, N. Oetjens, M. Fowke, J. Zheng, W. Spencer, K. Ritchie, M. Pendergrass, S. Le Marchand£££Loïc£££ L. Wilkens, L. Park, L. Tiirikainen, M. Kolonel, L. Lim, U. Cheng, I. Wang, H. Shohet, R. Haiman, C. Stram, D. Henderson, B. Monroe, K. Schumacher, F. Peters, U. Anderson, G. Carlson, C. Prentice, R. LaCroix, A. Wu, C. Carty, C. Gong, J. Rosse, S. Young, A. Haessler, J. Kocarnik, J. Lin, Y. Jackson, R. Duggan, D. Kuller, L. Stolk, L. He, C. Sulem, P. Barbalic, M. Broer, L. Byrne, EM. Gudbjartsson, DF. McArdle, PF. Porcu, E. van Wingerden, S. Zhuang, W. Albrecht, E. Alizadeh, BZ. Lauc, LB. Broekmans, FJ. Burri, A. Chanock, SJ. Chen, C. Corre, T. Coviello, AD. d'Adamo, P. Davies, G. Deary, IJ. Ebrahim, S. Fauser, BC. Ferreli, L. Folsom, AR. Garcia, ME. Hall, P. Haller, T. Hankinson, SE. Hass, M. Heath, AC. Janssens, AC. Keyzer, J. Lahti, J. Lai, S. Laisk, T. Laven, JS. Liu, J. Lopez, LM. Louwers, YV. Marongiu, M. Klaric, IM. Masciullo, C. McKnight, B. Medland, SE. Melzer, D. Newman, AB. Paré, G. Peeters, PH. Plump, AS. Pop, VJ. Räikkönen, K. Salumets, A. Smith, JA. Stacey, SN. Starr, JM. Stathopoulou, MG. Tenesa, A. Thorand, B. Tryggvadottir, L. Tsui, K. van Dam RM. van Gils CH. van Nierop, P. Vink, JM. Voorhuis, M. Wallaschofski, H. Widen, E. Wijnands-van Gent CJ. Zgaga, L. Zygmunt, M. Arnold, AM. Buring, JE. Crisponi, L. Demerath, EW. Hunter, DJ. Schlessinger, D. Murray, A. Murabito, JM. Visser, JA. Lunetta, KL. Elks, CE. Cousminer, DL. Feenstra, B. Lin, P. van Wingerden SW. Smith, EN. Warrington, NM. Alavere, H. Barroso, I. Berenson, GS. Blackburn, H. Busonero, F. Chen, W. Couper, D. Easton, DF. Foroud, T. Geller, F. Hernandez, DG. Kilpeläinen, TO. Li, S. Melbye, M. Murray, JC. Murray, SS. Nelis, M. Ness, AR. Northstone, K. Pennell, CE. Pharoah, P. Rafnar, T. Rice, JP. Ring, SM. Schork, NJ. Segrè, AV. Sovio, U. Srinivasan, SR. Tammesoo, ML. Tyrer, J. Weedon, MN. Wichmann, H. Young, L. Zhuang, WV. Bierut, LJ. Boyd, HA. Department of Clinical Sciences Lund University [Lund] Genetic Epidemiology and Clinical Research Group Umea University Hospital Department of Odontology Umeå University Signalisation et Transports Ioniques Membranaires (STIM) Université de Poitiers-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS) Department of Medical Sciences Center for Biological Sequence Analysis [Lyngby] Danmarks Tekniske Universitet = Technical University of Denmark (DTU) Laboratory of Image Science and Technology [Nanjing] (LIST) Southeast University [Jiangsu]-School of Computer Science and Engineering Limnology Ecology Estonian Genome and Medicine University of Tartu Institute of Molecular and Cell Biology Department of Medical Epidemiology and Biostatistics (MEB) Karolinska Institutet [Stockholm] Department of Medical Genetics Université de Lausanne = University of Lausanne (UNIL) Institute of Medical Informatics, Biometry and Epidemiology Universität Duisburg-Essen = University of Duisburg-Essen [Essen] Centre d'Immunologie de Marseille - Luminy (CIML) Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) Genetic Epidemiology Unit Erasmus University Medical Center [Rotterdam] (Erasmus MC) Space Sciences Laboratory [Berkeley] (SSL) University of California [Berkeley] (UC Berkeley) University of California (UC)-University of California (UC) Department of Biostatistics and Center for Statistical Genetics University of Michigan [Ann Arbor] University of Michigan System-University of Michigan System Division of Statistical Genomics Washington University School of Medicine King‘s College London Department of Medicine University of Eastern Finland-Kuopio University Hospital Molecular Genetics Section University of Groningen [Groningen]-University Medical Centre Groningen Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)) Institut Pasteur de Lille Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS) Geriatric Rehabilitation Unit Azienda Sanitaria Firenze Department of Pharmacy Sciences Creighton University Medical Center Medical Department III Universität Leipzig Foie, métabolismes et cancer Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Department of Epidemiology Erasmus Medical Centre Netherlands Genomics Initiative (NGI) Netherlands Genomics Initiative Institute of Epidemiology [Neuherberg] (EPI) German Research Center for Environmental Health - Helmholtz Center München (GmbH) Department of Public Health and Clinical Medicine Medstar Research Institute Genetics and Pathology Finnish Institute of Occupational Health Epidemiology University Medical Centre Groningen Departments of Microbiology & Molecular Genetics and Molecular Biology & Biochemistry University of California [Irvine] (UC Irvine) Department of Odontology, Cariology Institute of Human Genetics Helmholtz Zentrum München = German Research Center for Environmental Health Génétique des maladies multifactorielles (GMM) Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS) Division of Cardiology Geneva University Hospital (HUG) Department of Psychiatry and Psychotherapy Rheinische Friedrich-Wilhelms-Universität Bonn Department of Physics Indian Institute of Technology Kanpur (IIT Kanpur) University of North Carolina [Chapel Hill] (UNC) University of North Carolina System (UNC)-University of North Carolina System (UNC) Department of Genomics, Life and Brain Center Universität Bonn = University of Bonn Anaesthesia and Intensive care Royal Aberdeen Childrens Hospital UCL Institute of neurology UCL Institute of Neurology Human Genetics The Wellcome Trust Sanger Institute [Cambridge] Departments of Epidemiology and Nutrition Harvard School of Public Health Institute of Experimental Medicine Czech Academy of Sciences [Prague] (CAS) Department of Medical Sciences and Uppsala Clinical Research Center Uppsala University Hospital Department of Genetics University of Groningen [Groningen] deCODE Genetics deCODE genetics [Reykjavik] Pediatric Pulmonology, Allergology & Epidemiology University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD Department of Nutrition-Dietetics Harokopio University of Athens Yale School of Medicine [New Haven, Connecticut] (YSM) National Heart and Lung Institute (NHLI) Imperial College London Queensland Institute of Medical Research Concord Hospital Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé Dept. Atherosclerose Kidney Center University Medical Center Groningen [Groningen] (UMCG) Department of Public Health & Primary Care University of Cambridge [UK] (CAM) Department of cardiology The Wellcome Trust Centre for Human Genetics [Oxford] University of Oxford Department of Internal Medicine University of Pisa - Università di Pisa MRC Epidemiology Unit University of Cambridge [UK] (CAM)-Institute of Metabolic Science Health Sciences Research Institute Warwick Department of Nephrology University Medical Center, University of Groningen Institute of Genetic Epidemiology Icelandic Heart Association Heart Preventive Clinic and Research Institute University of Iceland [Reykjavik] Executive Board Polycystic Kidney Disease Charity (PKD Charity)-Ciliopathy Alliance-International Alliance Department of Zoology University of Otago [Dunedin, Nouvelle-Zélande] Institute for Community Medicine, Department Epidemiology of Health Care and Community Health Universität Greifswald - University of Greifswald Interfaculty Institute for Genetics and Functional Genomics 5 University Street Centre for Paediatric Epidemiology and Biostatistics University College of London [London] (UCL) MRC Centre for Epidemiology of Child Health UCL Institute of Child Health Unit for Molecular Epidemiology Institute of Health Sciences and Biocenter Oulu University of Oulu Department of Epidemiology and Biostatistics Department of Life Course and Services National Institute for Health and Welfare [Helsinki] Department of Epidemiology and Public Health Queen's University [Belfast] (QUB) Interdisciplinary Center of Clinical Research Department of Physiology University of Eastern Finland-Institute of Biomedicine University of Hawai‘i [Mānoa] (UHM) Department of Clinical Chemistry University of Tampere [Finland]-Tampere University Hospital Chronic Disease Epidemiology and Prevention Unit Université Laval [Québec] (ULaval) Centre for Bone and Arthritis Research University of Gothenburg (GU)-Institute of Medicine Interdisciplinary Center for Psychiatric Epidemiology Medical Research Council Epidemiology Unit, Institute of Metabolic Science Addenbrooke's Hospital The Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Department of Clinical Physiology Turku University Hospital (TYKS) Brigham and Women's Hospital [Boston] Department of Chronic Disease Prevention Department of Cardiovascular Sciences [Leicester] University of Leicester Leicester NIHR Biomedical Research Unit in Cardiovascular Disease Maastricht University [Maastricht] Institute of Social and Preventive Medicine Lausanne University Hospital Carl Gustav Carus University Hospital Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050) Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2) Institut de biologie de Lille - UMS 3702 (IBL) Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS) Institut Cochin (IC UM3 (UMR 8104 / U1016)) Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) HELIOS Klinikum Stralsund Hanseatic-Greifswald University Hospital Department of child and adolescent psychiatry Institute for Medical Informatics, Biometry, and Epidemiology MRC National Survey of Health and Development MRC Unit for Lifelong Health and Ageing Clinical Institute of Medical and Chemical Laboratory Diagnostics Karl-Franzens-Universität Graz Peter MacCallum Cancer Center Institute for Molecular Medicine Finland [Helsinki] (FIMM) Helsinki Institute of Life Science (HiLIFE) Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki Unit of Genetic Epidemiology and Bioinformatics, Department of 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Boston Children's Hospital Metabolism Initiative and Program in Medical and Population Genetics Broad Institute of MIT and Harvard (BROAD INSTITUTE) Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston] University of North Carolina System (UNC)-University of North Carolina System (UNC)-UNC Gillings School of Global Public Health-Carolina Center for Genome Sciences Metabolic Disease Group University of Cambridge Metabolic Research Laboratories Institute of Metabolic Science Department of Epidemiology and Preventive Medicine Regensburg University Medical Center Epidemiology Unit Addenbrooke's Hospital-Medical Research Council (MRC) Framingham Heart Study Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI) Endocrinology and Metabolism The Churchill Hospital-Oxford Centre for Diabetes Landsteiner Laboratory Clinical Haematology Other departments ACS - Amsterdam Cardiovascular Sciences Vascular Medicine Lund University Diabetes Centre-Lund University [Lund] Université de Tours-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers Technical University of Denmark [Lyngby] (DTU) Université de Lausanne (UNIL) Universität Duisburg-Essen [Essen] Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU) University of California [Berkeley] University of California-University of California Génomique Intégrative et Modélisation des Maladies Métaboliques (EGID) Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS) Universität Leipzig [Leipzig] Université de Rennes 1 (UR1) Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) University of California [Irvine] (UCI) German Research Center for Environmental Health University of Bonn Czech Academy of Sciences [Prague] (ASCR) Yale University School of Medicine University of Oxford [Oxford] German Research Center for Environmental Health-Helmholtz-Zentrum München (HZM) Laval University Laval University [Québec] Turku University Hospital Lausanne university hospital Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES) Institut de biologie de Lille - IBL (IBLI) Université de Lille, Sciences et Technologies-Institut Pasteur de Lille Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS) University of Helsinki-University of Helsinki Helmholtz-Zentrum München (HZM) National Heart, Lung, and Blood Institute [Bethesda] (NHLBI)-Boston University [Boston] (BU) Internal Medicine Child and Adolescent Psychiatry / Psychology Clinical Genetics Medical Informatics Obstetrics & Gynecology Lund University [Lund]-Lund University Diabetes Centre Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (GI3M) Institute of Medicine-University of Gothenburg (GU) Signalisation et Transports Ioniques Membranaires ( STIM ) Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ) Technical University of Denmark [Lyngby] ( DTU ) Laboratory of Image Science and Technology [Nanjing] ( LIST ) Department of Medical Epidemiology and Biostatistics ( MEB ) University of Lausanne Centre d'Immunologie de Marseille - Luminy ( CIML ) Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) Erasmus MC Space Sciences Laboratory [Berkeley] ( SSL ) Génomique Intégrative et Modélisation des Maladies Métaboliques ( EGID ) Université de Lille-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Pasteur de Lille Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ) University of Leipzig Université de Rennes 1 ( UR1 ) Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) Institute of Epidemiology [Neuherberg] ( EPI ) University of California [Irvine] ( UCI ) Génétique des maladies multifactorielles ( GMM ) Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ) Geneva University Hospital ( HUG ) Bonn Universität [Bonn] Indian Institute of Technology Kanpur ( IIT Kanpur ) The University of North Carolina at Chapel Hill Université de Bonn Wellcome Trust Sanger Institute Harvard University School of Public Health Czech Academy of Sciences [Prague] ( ASCR ) deCODE genetics University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD Yale School of Medicine National Heart and Lung Institute ( NHLI ) Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé University Medical Center Groningen University of Cambridge [UK] ( CAM ) Wellcome Trust Centre for Human Genetics University of Pisa [Pisa] University of Cambridge [UK] ( CAM ) -Institute of Metabolic Science German Research Center for Environmental Health-Helmholtz-Zentrum München ( HZM ) University of Otago University of Greifswald University College of London [London] ( UCL ) National Institute for Health and Welfare Queen's University [Belfast] ( QUB ) University of Hawaii at Manoa ( UHM ) University of Gothenburg ( GU ) -Institute of Medicine Recherches en Psychopathologie, nouveaux symptômes et lien social ( EA 4050 ) Université de Poitiers-Université de Brest ( UBO ) -Université Catholique de l'Ouest-Université de Rennes 2 ( UR2 ) Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) Institut de biologie de Lille - IBL ( IBLI ) Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ) Institut Cochin ( UM3 (UMR 8104 / U1016) ) Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) University Medicine Greifswald,-HELIOS Hospital Stralsund Finland Institute for Molecular Medicine ( FIMM ) Georgia Prevention Institute Netherlands Consortium for Healthy Aging Helmholtz-Zentrum München ( HZM ) National Institutes of Health ( NIH ) -National Cancer Institute ( NIH ) Massachusetts General Hospital Children's Hospital, Boston Broad Institute, Cambridge, MA The University of North Carolina at Chapel Hill-UNC Gillings School of Global Public Health-Carolina Center for Genome Sciences Shungin D, Winkler TW Adipogen, Consortium Cardiogramplusc4d, Consortium Ckdgen, Consortium Gefos, Consortium Genie, Consortium Glgc Icbp International, Endogene Consortium Lifelines, Cohort Study Magic, Investigator Muther, Consortium Consortium, Page ReproGen Consortium, Amouyel P D'Adamo, ADAMO PIO Gasparini, Paolo Shungin, Dmitry Winkler, Thomas W Croteau-Chonka, Damien C Ferreira, Teresa Hypponen, Elina Mohlke, Karen L ADIPOGEN Consortium Int Endogene Consortium Lee Kong Chian School of Medicine (LKCMedicine) Epidemiologie RS: CARIM - R3.02 - Hypertension and target organ damage Université de Tours-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS) Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) Biological Psychology Neuroscience Campus Amsterdam - Neurobiology of Mental Health EMGO+ - Lifestyle, Overweight and Diabetes Damage and Repair in Cancer Development and Cancer Treatment (DARE) Guided Treatment in Optimal Selected Cancer Patients (GUTS) Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE) Life Course Epidemiology (LCE) Cardiovascular Centre (CVC) Groningen Kidney Center (GKC) Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) Groningen Research Institute for Asthma and COPD (GRIAC) Groningen Institute for Organ Transplantation (GIOT) Lifestyle Medicine (LM) Center for Liver, Digestive and Metabolic Diseases (CLDM) Stem Cell Aging Leukemia and Lymphoma (SALL) Shungin, D Winkler, T Croteau Chonka, D Ferreira, T Locke, A Mägi, R Strawbridge, R Pers, T Fischer, K Justice, A Workalemahu, T Wu, J Buchkovich, M Heard Costa, N Roman, T Drong, A Song, C Gustafsson, S Day, F Esko, T Fall, T Kutalik, Z Luan, J Randall, J Scherag, A Vedantam, S Wood, A Chen, J Fehrmann, R Karjalainen, J Kahali, B Liu, C Schmidt, E Absher, D Amin, N Anderson, D Beekman, M Bragg Gresham, J Buyske, S Demirkan, A Ehret, G Feitosa, M Goel, A Jackson, A Johnson, T Kleber, M Kristiansson, K Mangino, M Leach, I Medina Gomez, C Palmer, C Pasko, D Pechlivanis, S Peters, M Prokopenko, I Stanca'Kova', A Sung, Y Tanaka, T Teumer, A Van Vliet Ostaptchouk, J Yengo, L Zhang, W Albrecht, E Ärnlöv, J Arscott, G Bandinelli, S Barrett, A Bellis, C Bennett, A Berne, C Blüher, M Böhringer, S Bonnet, F Böttcher, Y Bruinenberg, M Carba, D Caspersen, I Clarke, R Daw, E Deelen, J Deelman, E Delgado, G Doney, A Eklund, N Erdos, M Estrada, K Eury, E Friedrich, N Garcia, M Giedraitis, V Gigante, B Go, A Golay, A Grallert, H Grammer, T Gräsler, J Grewal, J Groves, C Haller, T Hallmans, G Hartman, C Hassinen, M Hayward, C Heikkilä, K Herzig, K Helmer, Q Hillege, H Holmen, O Hunt, S Isaacs, A Ittermann, T James, A Johansson, I Juliusdottir, T Kalafati, I Kinnunen, L Koenig, W Kooner, I Kratzer, W Lamina, C Leander, K Lee, N Lichtner, P Lind, L Lindström, J Lobbens, S Lorentzon, M Mach, F Magnusson, P Mahajan, A Mcardle, W Menni, C Merger, S Mihailov, E Milani, L Mills, R Moayyeri, A Monda, K Mooijaart, S Mühleisen, T Mulas, A Müller, G Müller Nurasyid, M Nagaraja, R Nalls, M Narisu, N Glorioso, N Nolte, I Olden, M Rayner, N Renstrom, F Ried, J Robertson, N Rose, L Sanna, S Scharnagl, H Scholtens, S Sennblad, B Seufferlein, T Sitlani, C Smith, A Stirrups, K Stringham, H Sundström, J Swertz, M Swift, A Syvänen, A Tayo, B Thorand, B Thorleifsson, G Tomaschitz, A Troffa, C Van Oort, F Verweij, N Vonk, J Waite, L Wennauer, R Wilsgaard, T Wojczynski, M Wong, A Zhang, Q Zhao, J Brennan, E Choi, M Eriksson, P Folkersen, L Franco Cereceda, A Gharavi, A Hedman, A Hivert, M Huang, J Kanoni, S Karpe, F Keildson, S Kiryluk, K Liang, L Lifton, R Ma, B Mcknight, A Mcpherson, R Metspalu, A Min, J Moffatt, M Montgomery, G Murabito, J Nicholson, G Nyholt, D Olsson, C Perry, J Reinmaa, E Salem, R Sandholm, N Schadt, E Scott, R Stolk, L Vallejo, E Westra, H Zondervan, K Amouyel, P Arveiler, D Bakker, S Beilby, J Bergman, R Blangero, J Brown, M Burnier, M Campbell, H Chakravarti, A Chines, P Claudi Boehm, S Collins, F Crawford, D Danesh, J De Faire, U De Geus, E Dörr, M Erbel, R Eriksson, J Farrall, M Ferrannini, E Ferrières, J Forouhi, N Forrester, T Franco, O Gansevoort, R Gieger, C Gudnason, V Haiman, C Harris, T Hattersley, A Heliövaara, M Hicks, A Hingorani, A Hoffmann, W Hofman, A Homuth, G Humphries, S Hyppönen, E Illig, T Jarvelin, M Johansen, B Jousilahti, P Jula, A Kaprio, J Kee, F Keinanen Kiukaanniemi, S Kooner, J Kooperberg, C Kovacs, P Kraja, A Kumari, M Kuulasmaa, K Kuusisto, J Lakka, T Langenberg, C Le Marchand, L Lehtimäki, T Lyssenko, V Männistö, S Marette, A Matise, T Mckenzie, C Mcknight, B Musk, A Möhlenkamp, S Morris, A Nelis, M Ohlsson, C Oldehinkel, A Ong, K Palmer, L Penninx, B Peters, A Pramstaller, P Raitakari, O Rankinen, T Rao, D Rice, T Ridker, P Ritchie, M Rudan, I Salomaa, V Samani, N Saramies, J Sarzynski, M Schwarz, P Shuldiner, A Staessen, J Steinthorsdottir, V Stolk, R Strauch, K Tönjes, A Tremblay, A Tremoli, E Vohl, M Völker, U Vollenweider, P Wilson, J Witteman, J Adair, L Bochud, M Boehm, B Bornstein, S Bouchard, C Cauchi, S Caulfield, M Chambers, J Chasman, D Cooper, R Dedoussis, G Ferrucci, L Froguel, P Grabe, H Hamsten, A Hui, J Hveem, K Jöckel, K Kivimaki, M Kuh, D Laakso, M Liu, Y März, W Munroe, P Njolstad, I Oostra, B Pedersen, N Perola, M Pe'Russe, L Peters, U Power, C Quertermous, T Rauramaa, R Rivadeneira, F Saaristo, T Saleheen, D Sinisalo, J Slagboom, P Snieder, H Spector, T Thorsteinsdottir, U Stumvoll, M Tuomilehto, J Uitterlinden, A Uusitupa, M Van Der Harst, P Veronesi, G Walker, M Wareham, N Watkins, H Wichmann, H Abecasis, G Assimes, T Berndt, S Boehnke, M Borecki, I Deloukas, P Franke, L Frayling, T Groop, L Hunter, D Kaplan, R O'Connell, J Qi, L Schlessinger, D Strachan, D Stefansson, K Van Duijn, C Willer, C Visscher, P Yang, J Hirschhorn, J Zillikens, M Mccarthy, M Speliotes, E North, K Fox, C Barroso, I Franks, P Ingelsson, E Heid, I Loos, R Cupples, L Lindgren, C Mohlke, K Dastani, Z Timpson, N Yuan, X Henneman, P Kizer, J Lyytikainen, L Fuchsberger, C Small, K Coassin, S Lohman, K Pankow, J Uh, H Wu, Y Bidulescu, A Rasmussen Torvik, L Greenwood, C Ladouceur, M Grimsby, J Manning, A Mooser, V Kapur, K Frants, R Willemsvan vanDijk, K Willems, S Psaty, B Tracy, R Brody, J Chen, I Viikari, J Kähönen, M Evans, D St Pourcain, B Sattar, N Carlson, O Egan, J van Heemst, D Kedenko, L Nuotio, M Loo, B Kanaya, A Haun, M Klopp, N Katsareli, E Couper, D Duncan, B Kloppenburg, M Borja, J Musani, S Guo, X Semple, R Teslovich, T Allison, M Redline, S Buxbaum, S Meulenbelt, I Ballantyne, C Hu, F Paulweber, B Florez, J Smith, G Siscovick, D Kronenberg, F van Duijn, C Waterworth, D Meigs, J Dupuis, J Richards, J Willenborg, C Thompson, J Erdmann, J Goldstein, B König, I Cazier, J Johansson, Å Hall, A Lee, J Grundberg, E Havulinna, A Ho, W Hopewell, J Eriksson, N Lundmark, P Lyytikäinen, L Rafelt, S Tikkanen, E Van Zuydam, N Voight, B Ziegler, A Altshuler, D Balmforth, A Braund, P Burgdorf, C Cox, D Dimitriou, M Do, R El Mokhtari, N Fontanillas, P Hager, J Han, B Kang, H Kessler, T Knowles, J Kolovou, G Langford, C Lokki, M Lundmark, A 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Murgia, F Trompet, S Imboden, M Kollerits, B Pistis, G Launer, L Aspelund, T Eiriksdottir, G Mitchell, B Schmidt, H Cavalieri, M Rao, M de Andrade, M Turner, S Ding, J Andrews, J Freedman, B Döring, A Kolcic, I Zemunik, T Boban, M Minelli, C Wheeler, H Igl, W Zaboli, G Wild, S Wright, A Ellinghaus, D Nöthlings, U Jacobs, G Biffar, R Endlich, K Ernst, F Kroemer, H Nauck, M Stracke, S Völzke, H Aulchenko, Y Polasek, O Hastie, N Vitart, V Helmer, C Wang, J Ruggiero, D Bergmann, S Nikopensius, T Province, M Ketkar, S Colhoun, H Robino, A Giulianini, F Krämer, B Portas, L Ford, I Buckley, B Adam, M Thun, G Sala, C Metzger, M Mitchell, P Ciullo, M Kim, S Gasparini, P Pirastu, M Jukema, J Probst Hensch, N Toniolo, D Coresh, J Schmidt, R Kardia, S Curhan, G Gyllensten, U Franke, A Rettig, R Parsa, A Goessling, W Kao, W de Boer, I Peralta, C Akylbekova, E Kramer, H van der Harst, P Arking, D Franceschini, N Hernandez, D Townsend, R Lumley, T Kestenbaum, B Haritunians, T Waeber, G Lu, X Leak, T 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Wainwright, N Wijmenga, C Willemsen, G Young, E Bennett, F Boomsma, D Bovet, P Chen, Y Feranil, A Freimer, N Hsiung, C Järvelin, M Kesäniemi, A Koudstaal, P Krauss, R Kyvik, K Martin, N Meneton, P Moilanen, L Njølstad, I Price, J Sanghera, D Sheu, W Whitfield, J Wolffenbuttel, B Ordovas, J Rich, S Johnson, L Larson, M Levy, D Newton Cheh, C O'Reilly, P Palmas, W Rice, K Snider, H Tobin, M Verwoert, G Pihur, V Heath, S Sõber, S Arora, P Zhang, F Lucas, G Milaneschi, Y Parker, A Fava, C Fox, E Go, M Sjögren, M Vinay, D Alexander, M Tabara, Y Shaw Hawkins, S Whincup, P Shi, G Seielstad, M Sim, X Nguyen, K Matullo, G Gaunt, T Onland Moret, N Cooper, M Platou, C Org, E Hardy, R Dahgam, S Palmen, J Kuznetsova, T Uiterwaal, C Adeyemo, A Ludwig, B Tomaszewski, M Tzoulaki, I Palmer, N Chang, Y Steinle, N Grobbee, D Morrison, A Najjar, S Hadley, D Connell, J Day, I Lawlor, D Lawrence, R Ongen, H Li, Y Young, J Bis, J Chaturvedi, N Islam, M Jafar, T Kulkarni, S Grässler, J Howard, P Guarrera, S 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Psychiatry NCA - Neurobiology of mental health EMGO - Lifestyle, overweight and diabetes
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Nature Publishing Group, Nature, 518(7538), 187-U378, Shungin, D, Winkler, T W, Croteau-Chonka, D C, Ferreira, T, Lockes, A E, Maegi, R, Strawbridge, R J, Pers, T H, Fischer, K, Justice, A E, Workalemahu, T, Wu, J M W, Buchkovich, M L, Heard-Costa, N L, Roman, T S, Drong, A W, Song, C, Gustafsson, S, Day, F R, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J C, Scherag, A, Vedantam, S, Wood, A R, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg-Gresham, J L, Buyske, S, Demirkan, A, Ehret, G B, Feitosa, M F, Goel, A, Jackson, A U, Johnson, T, Kleber, M E, Kristiansson, K, Mangino, M, Leach, I M, Medina-Gomez, C, Palmer, C D, Pasko, D, Pechlivaniss, S, Peters, MJ, Prokopenko, I, Stancakova, A, Sung, Y J, Tanakam, T, Teumer, A, van Vliet-Ostaptchouk, J V, Yengo, L, Zhang, W, Albrecht, E, Arnlov, J, Arscott, G M, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A J, Berne, C, Blueher, M, Buhringer, S, Bonnet, F, Boettcher, Y, Bruinenberg, M, Carba, D B, Caspersen, I H, Clarke, R, Daw, E W, Deelen, J, Deelman, E, Delgado, G, Doney, A S F, Eklund, N, Erdos, M R, Estrada, K, Eury, E, Friedrichs, N, Garcia, M E, Giedraitis, V, Gigante, B, Go, A S, Golay, A, Grallert, H, Grammer, T B, Graessler, J, Grewal, J, Groves, C J, Haller, T, Hallmans, G, Hartman, C A, Hassinen, M, Hayward, C, Heikkila, K, Herzig, K, Helmer, Q, Hillege, H L, Holmen, O, Hunt, S C, Isaacs, A, Ittermann, T, James, A L, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I K, Kratzer, W, Lamina, C, Leander, K, Lee, N R, Lichtner, P, Lind, L, Lindstrom, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P K E, Mahajan, A, McArdle, W L, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K L, Mooijaart, S P, Muehleisen, T W, Mulas, A, Mueller, G, Mueller-Nurasyid, M, Nagaraja, R, Nalls, M A, Narisu, N, Glorioso, N, Nolte, I M, Olden, M, Rayner, N W, Renstrom, F, Ried, J S, Robertson, N R, Rose, L M, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C M, Smith, A V, Stirrups, K, Stringham, H M, Sundstrom, J, Swertz, M A, Swift, A J, Syvanen, A, Tayo, B O, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, van Oort, F V A, Verweij, N, Vonk, J M, Waite, L L, Wennauer, R, Wilsgaard, T, Wojczynski, M K, Wong, A, Zhang, Q, Zhao, J H, Brennan, E P, Choi, M, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Gharavi, A G, Hedman, A K, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R P, Ma, B, McKnight, A J, McPherson, R, Metspalu, A, Min, J L, Moffatt, M F, Montgomery, G W, Murabito, J M, Nicholson, G, Nyholt, DR, Olsson, C, Perry, J R B, Reinmaa, E, Salem, R M, Sandholm, N, Schadt, E E, Scott, R A, Stolk, L, Vallejo, E E, Westra, H, Zondervan, K T, Amouyel, P, Arveiler, D, Bakker, S J L, Beilby, J, Bergman, R N, Blangero, J, Brown, M J, Burnier, M, Campbell, H, Chakravarti, A, Chiness, P S, Claudi-Boehmi, S, Collins, F S, Crawford, D C, Danesh, J, de Faire, U, de Geus, E J C, Doerr, M, Erbel, R, Eriksson, J G, Farrall, M, Ferrannini, E, Ferrieres, J, Forouhi, N G, Forrester, T, Franco, O H, Gansevoort, R T, Gieger, C, Gudnason, V, Haiman, C A, Harris, T B, Hattersley, A T, Heliovaara, M, Hicks, A A, Hingorani, A D, Hoffmann, W, Hofman, A, Homuth, G, Humphries, S E, Hyppoenen, E, Illig, T, Jarvelin, M, Johansen, B, Jousilahti, P, Jula, A M, Kaprio, J, Kee, F, Keinanen-Kiukaanniemi, S M, Kooner, J S, Kooperberg, C, Kovacs, P, Kraja, A T, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, T A, Langenberg, C, Le Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T C, McKenzie, C A, McKnight, B, Musk, A W, Mohlenkamp, S, Morris, A D, Nelis, M, Ohlsson, C, Oldehinkel, A J, Ong, K K, Palmer, L J, Penninx, B W J H, Peters, A, Pramstaller, P P, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Ridker, P M, Ritchie, M D, Rudan, I, Salomaa, V, Samani, N J, Saramies, J, Sarzynski, M A, Schwarz, P E H, Shuldiner, A R, Staessen, J A, Steinthorsdottir, V, Stolk, R P, Strauch, K, Toenjes, A, Tremblay, A, Tremoli, E, Vohl, M, Voelker, U, Vollenweider, P, Wilson, J F, Witteman, J C, Adair, L S, Bochud, M, Boehm, B O, Bornstein, S R, Bouchard, C, Cauchi, S, Caulfield, M J, Chambers, J C, Chasman, D I, Cooper, R S, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H, Hamsten, A, Hui, J, Hveem, K, Joeckel, K, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Maerz, W, Munroe, P B, Njolstad, I, Oostra, B A, Palmer, C N A, Pedersen, N L, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T E, Saleheen, D, Sinisalo, J, Slagboom, P E, Snieder, H, Spector, T D, Thorsteinsdottir, U R, Stumvoll, M, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van der Harst, P, Veronesi, G, Walker, M, Wareham, N J, Watkins, H, Wichmann, H, Abecasis, G R, Assimes, T L, Berndt, S I, Boehnkes, M, Borecki, I B, Deloukas, P, Franke, L, Frayling, T M, Groop, L C, Hunter, D J, Kaplan, R C, O'Connell, J R, Qi, L, Schlessinger, D, Strachan, D P, Stefansson, K, van Dujin, C M, Willer, C J, Visscher, P M, Yang, J, Hirschhorn, J N, Zillikens, M C, McCarthy, M I, Speliotes, E K, North, K E, Fox, C S, Barroso, I, Franks, P W, Ingelsson, E, Heid, I M, Loos, R J F, Cupples, L A, Morris, A P, Lindgren, C M & Mohlke, K L 2015, ' New genetic loci link adipose and insulin biology to body fat distribution ', Nature, vol. 518, no. 7538, pp. 187-196 . https://doi.org/10.1038/nature14132, Nature, Nature Publishing Group, 2015, 518 (7538), pp.187-96. 〈10.1038/nature14132〉, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid
Publication Year :
2015
Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
Subjects
Subjects :
Adipose Tissue/metabolism Male genetic association subcutaneous fat Transcription, Genetic Adipocytes Adipogenesis Adipose Tissue Age Factors Body Mass Index Continental Population Groups Epigenesis, Genetic Europe Female Genome, Human Humans Insulin Insulin Resistance Models, Biological Neovascularization, Physiologic Obesity Polymorphism, Single Nucleotide Quantitative Trait Loci Sex Characteristics Waist-Hip Ratio Body Fat Distribution Genome-Wide Association Study Multidisciplinary Insulin Resistance/genetics Genome-wide association study Continental Population Groups/genetics genetic analysis heritability gene cluster Science::Biological sciences::Human anatomy and physiology [DRNTU] 0302 clinical medicine high density lipoprotein cholesterol Models genetics [Insulin Resistance] histone modification Age Factor insulin receptor 0303 health sciences Adipocyte Human/genetics CARDIOGRAMplusC4D Consortium ADIPOGENIC DIFFERENTIATION genetic correlation body fat Continental Population Group priority journal 5 trisphosphate 3 phosphatase GEFOS Consortium meta analysis (topic) Science & Technology - Other Topics ddc:500 transcription regulation Adipogenesis/genetics Single Nucleotide/genetics Human medicine.medical_specialty Waist phosphatidylinositol 3 European ta3111 genetic regulation Article developmental biology 03 medical and health sciences MAGIC Investigators transcription initiation site SDG 3 - Good Health and Well-being Genetic genomics GLYCEMIC TRAITS genetics [Continental Population Groups] Polymorphism GENOME-WIDE ASSOCIATION Physiologic genetics [Adipogenesis] Adipocytes/metabolism Europe/ethnology Genome, Human/genetics Insulin/metabolism Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics Transcription, Genetic/genetics Genetic/genetics Adipogenesi Science & Technology adiponectin [ SDV ] Life Sciences [q-bio] vasculotropin genetics [Quantitative Trait Loci] ta1184 Racial Groups ta1182 gene mapping ta3121 triacylglycerol blood level medicine.disease Biological major clinical study amino acid sequence metabolism [Insulin] Endocrinology metabolism [Adipocytes] genetic loci, insulin, body fat GLGC International Endogene Consortium metabolism [Adipose Tissue] Body mass index HUMAN HEIGHT Epigenesis LifeLines Cohort Study ReproGen Consortium BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA tissue level Physiologic/genetics [SDV]Life Sciences [q-bio] Medizin Adipose tissue low density lipoprotein cholesterol PAGE Consortium COMMON SNPS angiogenesis Waist–hip ratio genetics [Obesity] MESH: Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism* Age Factors Body Fat Distribution* Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study* Humans Insulin/metabolism* Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics* Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio single nucleotide polymorphism fat genetic variability molecular biology body mass index (BMI) ethnology [Europe] peroxisome proliferator activated receptor 2. Zero hunger Genetics Genome Single Nucleotide waist circumference insulin phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase triacylglycerol vasculotropin, developmental biology gene expression genome numerical model, adipocyte adipose tissue body fat distribution body mass female gene locus gene structure hip circumference human insulin resistance lipoprotein blood level male obesity protein protein interaction sex difference waist hip ratio Multidisciplinary Sciences genetics [Transcription, Genetic] genetics [Polymorphism, Single Nucleotide] ADIPOGen Consortium genetics [Neovascularization, Physiologic] Transcription SUSCEPTIBILITY LOCI General Science & Technology ICBP 030209 endocrinology & metabolism Biology adipocyte MESH : Adipocytes/metabolism Adipogenesis/genetics Adipose Tissue/metabolism* Age Factors Body Fat Distribution* Body Mass Index Continental Population Groups/genetics Epigenesis, Genetic Europe/ethnology Female Genome, Human/genetics Genome-Wide Association Study* Humans Insulin/metabolism* Insulin Resistance/genetics Male Models, Biological Neovascularization, Physiologic/genetics Obesity/genetics Polymorphism, Single Nucleotide/genetics Quantitative Trait Loci/genetics* Sex Characteristics Transcription, Genetic/genetics Waist-Hip Ratio MESENCHYMAL STEM-CELLS GENIE Consortium SEXUAL-DIMORPHISM Insulin resistance Internal medicine medicine genetics [Genome, Human] ABDOMINAL ADIPOSITY Neovascularization 030304 developmental biology FALSE DISCOVERY CKDGen Consortium Sex Characteristic MuTHER Consortium numerical model
Details
Language :
English
ISSN :
00280836, 14764687, and 14764679
Database :
OpenAIRE
Journal :
Nature, vol. 518, no. 7538, pp. 187-196, Nature, Nature, 2015, 518 (7538), pp.187-96. ⟨10.1038/nature14132⟩, Nature <London> 518(7538), 187-196 (2015). doi:10.1038/nature14132, Nature, 518(7538), 187-U378. Nature Publishing Group, Nature, Nature Publishing Group, 2015, 518 (7538), pp.187-96. ⟨10.1038/nature14132⟩, Nature, 518(7538), 187-196. Nature Publishing Group, Nature, 518(7538), 187. Nature Publishing Group, Nature, 518(7538), 187-U378, Shungin, D, Winkler, T W, Croteau-Chonka, D C, Ferreira, T, Lockes, A E, Maegi, R, Strawbridge, R J, Pers, T H, Fischer, K, Justice, A E, Workalemahu, T, Wu, J M W, Buchkovich, M L, Heard-Costa, N L, Roman, T S, Drong, A W, Song, C, Gustafsson, S, Day, F R, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J C, Scherag, A, Vedantam, S, Wood, A R, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E M, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg-Gresham, J L, Buyske, S, Demirkan, A, Ehret, G B, Feitosa, M F, Goel, A, Jackson, A U, Johnson, T, Kleber, M E, Kristiansson, K, Mangino, M, Leach, I M, Medina-Gomez, C, Palmer, C D, Pasko, D, Pechlivaniss, S, Peters, MJ, Prokopenko, I, Stancakova, A, Sung, Y J, Tanakam, T, Teumer, A, van Vliet-Ostaptchouk, J V, Yengo, L, Zhang, W, Albrecht, E, Arnlov, J, Arscott, G M, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A J, Berne, C, Blueher, M, Buhringer, S, Bonnet, F, Boettcher, Y, Bruinenberg, M, Carba, D B, Caspersen, I H, Clarke, R, Daw, E W, Deelen, J, Deelman, E, Delgado, G, Doney, A S F, Eklund, N, Erdos, M R, Estrada, K, Eury, E, Friedrichs, N, Garcia, M E, Giedraitis, V, Gigante, B, Go, A S, Golay, A, Grallert, H, Grammer, T B, Graessler, J, Grewal, J, Groves, C J, Haller, T, Hallmans, G, Hartman, C A, Hassinen, M, Hayward, C, Heikkila, K, Herzig, K, Helmer, Q, Hillege, H L, Holmen, O, Hunt, S C, Isaacs, A, Ittermann, T, James, A L, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I K, Kratzer, W, Lamina, C, Leander, K, Lee, N R, Lichtner, P, Lind, L, Lindstrom, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P K E, Mahajan, A, McArdle, W L, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K L, Mooijaart, S P, Muehleisen, T W, Mulas, A, Mueller, G, Mueller-Nurasyid, M, Nagaraja, R, Nalls, M A, Narisu, N, Glorioso, N, Nolte, I M, Olden, M, Rayner, N W, Renstrom, F, Ried, J S, Robertson, N R, Rose, L M, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C M, Smith, A V, Stirrups, K, Stringham, H M, Sundstrom, J, Swertz, M A, Swift, A J, Syvanen, A, Tayo, B O, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, van Oort, F V A, Verweij, N, Vonk, J M, Waite, L L, Wennauer, R, Wilsgaard, T, Wojczynski, M K, Wong, A, Zhang, Q, Zhao, J H, Brennan, E P, Choi, M, Eriksson, P, Folkersen, L, Franco-Cereceda, A, Gharavi, A G, Hedman, A K, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R P, Ma, B, McKnight, A J, McPherson, R, Metspalu, A, Min, J L, Moffatt, M F, Montgomery, G W, Murabito, J M, Nicholson, G, Nyholt, DR, Olsson, C, Perry, J R B, Reinmaa, E, Salem, R M, Sandholm, N, Schadt, E E, Scott, R A, Stolk, L, Vallejo, E E, Westra, H, Zondervan, K T, Amouyel, P, Arveiler, D, Bakker, S J L, Beilby, J, Bergman, R N, Blangero, J, Brown, M J, Burnier, M, Campbell, H, Chakravarti, A, Chiness, P S, Claudi-Boehmi, S, Collins, F S, Crawford, D C, Danesh, J, de Faire, U, de Geus, E J C, Doerr, M, Erbel, R, Eriksson, J G, Farrall, M, Ferrannini, E, Ferrieres, J, Forouhi, N G, Forrester, T, Franco, O H, Gansevoort, R T, Gieger, C, Gudnason, V, Haiman, C A, Harris, T B, Hattersley, A T, Heliovaara, M, Hicks, A A, Hingorani, A D, Hoffmann, W, Hofman, A, Homuth, G, Humphries, S E, Hyppoenen, E, Illig, T, Jarvelin, M, Johansen, B, Jousilahti, P, Jula, A M, Kaprio, J, Kee, F, Keinanen-Kiukaanniemi, S M, Kooner, J S, Kooperberg, C, Kovacs, P, Kraja, A T, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, T A, Langenberg, C, Le Marchand, L, Lehtimaki, T, Lyssenko, V, Mannisto, S, Marette, A, Matise, T C, McKenzie, C A, McKnight, B, Musk, A W, Mohlenkamp, S, Morris, A D, Nelis, M, Ohlsson, C, Oldehinkel, A J, Ong, K K, Palmer, L J, Penninx, B W J H, Peters, A, Pramstaller, P P, Raitakari, O T, Rankinen, T, Rao, D C, Rice, T K, Ridker, P M, Ritchie, M D, Rudan, I, Salomaa, V, Samani, N J, Saramies, J, Sarzynski, M A, Schwarz, P E H, Shuldiner, A R, Staessen, J A, Steinthorsdottir, V, Stolk, R P, Strauch, K, Toenjes, A, Tremblay, A, Tremoli, E, Vohl, M, Voelker, U, Vollenweider, P, Wilson, J F, Witteman, J C, Adair, L S, Bochud, M, Boehm, B O, Bornstein, S R, Bouchard, C, Cauchi, S, Caulfield, M J, Chambers, J C, Chasman, D I, Cooper, R S, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H, Hamsten, A, Hui, J, Hveem, K, Joeckel, K, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, Maerz, W, Munroe, P B, Njolstad, I, Oostra, B A, Palmer, C N A, Pedersen, N L, Perola, M, Perusse, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T E, Saleheen, D, Sinisalo, J, Slagboom, P E, Snieder, H, Spector, T D, Thorsteinsdottir, U R, Stumvoll, M, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, van der Harst, P, Veronesi, G, Walker, M, Wareham, N J, Watkins, H, Wichmann, H, Abecasis, G R, Assimes, T L, Berndt, S I, Boehnkes, M, Borecki, I B, Deloukas, P, Franke, L, Frayling, T M, Groop, L C, Hunter, D J, Kaplan, R C, O'Connell, J R, Qi, L, Schlessinger, D, Strachan, D P, Stefansson, K, van Dujin, C M, Willer, C J, Visscher, P M, Yang, J, Hirschhorn, J N, Zillikens, M C, McCarthy, M I, Speliotes, E K, North, K E, Fox, C S, Barroso, I, Franks, P W, Ingelsson, E, Heid, I M, Loos, R J F, Cupples, L A, Morris, A P, Lindgren, C M & Mohlke, K L 2015, ' New genetic loci link adipose and insulin biology to body fat distribution ', Nature, vol. 518, no. 7538, pp. 187-196 . https://doi.org/10.1038/nature14132, Nature, Nature Publishing Group, 2015, 518 (7538), pp.187-96. 〈10.1038/nature14132〉, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid
Accession number :
edsair.doi.dedup.....b85bfcecc21bc571d9b494c320c32aef