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Secretin-induced Duodenal Aspirate of Pancreatic Juice (SIDA): Utility of Commercial Genetic Analysis
- Source :
- Anticancer Research. 40:4215-4221
- Publication Year :
- 2020
- Publisher :
- Anticancer Research USA Inc., 2020.
-
Abstract
- Background Secretin-induced duodenal aspiration (SIDA) of pancreatic duct fluid has been proposed for pancreatic neoplasm screening in very high-risk patients. We sought to determine the clinical yield and safety of commercially-analyzed SIDA samples in patients at moderately elevated risk. Patients and methods A prospectively maintained institutional database of pancreatic fluid DNA profiles was retrospectively reviewed. Results Fifty-seven patients underwent SIDA testing, most commonly for intraductal papillary mucinous neoplasms (n=43) and not otherwise specified solitary cysts (n=9). SIDA mutation yield was low compared to 37 concomitant endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) samples of pancreatic fluid: KRAS (2.5% vs. 40.0%), GNAS (2.6% vs. 11.1%) and allelic loss of heterozygosity (3.1% vs. 0%). Patients undergoing SIDA alone experienced no complications while 3 patients with concomitant EUS-FNA had post-procedural pancreatitis. Conclusion The genetic yield of commercially-analyzed SIDA samples was relatively low in a moderately elevated risk cohort. SIDA testing may have a better safety profile than EUS-FNA.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Duodenum
medicine.disease_cause
Gastroenterology
Pancreatic Juice
Secretin
Internal medicine
Databases, Genetic
medicine
GNAS complex locus
Humans
Genetic Testing
Sida
Aged
Pancreatic duct
biology
medicine.diagnostic_test
business.industry
DNA
General Medicine
Middle Aged
medicine.disease
biology.organism_classification
Pancreatic Neoplasms
medicine.anatomical_structure
Fine-needle aspiration
Oncology
Concomitant
Pancreatic juice
biology.protein
Pancreatitis
Female
KRAS
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....b856c61f582bfdbe42bdda6368717aae