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Pre-pregnancy serum complement C3 level is a predictor of preterm birth for pregnancies with systemic lupus erythematosus
- Source :
- Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021), Arthritis Research & Therapy
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background This study aimed to clarify predictors of preterm birth in pregnancy of women with systemic lupus erythematosus (SLE). We investigated the predictors of preterm birth before pregnancy from the perspective of the importance of preconception care. Methods We analysed fetal outcomes of 108 pregnancies in 74 SLE patients in a retrospective study. We compared pre-pregnancy clinical characteristics and disease activity in these women between the preterm birth and full-term birth groups to select predictive factors for preterm birth before pregnancy. Results Eighty-three of 108 pregnancies resulted in live births, of which 27 (25.0%) were preterm births. Pre-pregnancy serum complement 3 (C3) level was significantly lower in the preterm birth group (77.0 mg/dl) than the full-term birth group (87.5 mg/dl) (P = 0.029). Multivariate analysis identified history of lupus nephritis (odds ratio: 5.734, 95% CI 1.568–21.010, P = 0.008) and low C3 level (< 85 mg/dl) at pre-pregnancy (odds ratio 4.498, 95% CI 1.296–15.616, P = 0.018) as risk factors for preterm birth. The greater the number of these risk factors, the higher was the preterm birth rate (P = 0.0007). In the case of SLEDAI score ≤ 4, the preterm birth rate was higher in the pre-pregnancy low C3 group (< 85 mg/dl) (42.1%) than in the high C3 group (C3 ≥ 85 mg/dl) (14.7%) (P = 0.018). Conclusion For patients with a history of LN, treatment management focusing on pre-pregnancy serum complement levels is very important.
- Subjects :
- medicine.medical_specialty
Multivariate analysis
Lupus nephritis
Diseases of the musculoskeletal system
Preconception care
Birth rate
03 medical and health sciences
0302 clinical medicine
Systemic lupus erythematosus
Pregnancy
Internal medicine
medicine
Humans
Lupus Erythematosus, Systemic
030212 general & internal medicine
Retrospective Studies
030203 arthritis & rheumatology
Fetus
business.industry
Obstetrics
Infant, Newborn
Pregnancy Outcome
Retrospective cohort study
Complement C4
Preterm birth
Odds ratio
Complement C3
medicine.disease
Lupus Nephritis
Rheumatology
Pregnancy Complications
Serum complement 3 level
RC925-935
Premature Birth
Female
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14786362
- Volume :
- 23
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Arthritis Research & Therapy
- Accession number :
- edsair.doi.dedup.....b8537e3f9db8ef3dbf9b216991d1ae62