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Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 98(7)
- Publication Year :
- 2001
-
Abstract
- Ehrlichiae are responsible for important tick-transmitted diseases, including anaplasmosis, the most prevalent tick-borne infection of livestock worldwide, and the emerging human diseases monocytic and granulocytic ehrlichiosis. Antigenic variation of major surface proteins is a key feature of these pathogens that allows persistence in the mammalian host, a requisite for subsequent tick transmission. In Anaplasma marginale pseudogenes for two antigenically variable gene families, msp 2 and msp 3, appear in concert. These pseudogenes can be recombined into the functional expression site to generate new antigenic variants. Coordinated control of the recombination of these genes would allow these two gene families to act synergistically to evade the host immune response.
- Subjects :
- Pseudogene
Molecular Sequence Data
Ehrlichia
Biology
Tick
Antigenic Diversity
Epitopes
Bacterial Proteins
parasitic diseases
medicine
Antigenic variation
Gene family
Animals
Humans
Amino Acid Sequence
Genetics
Tick-borne disease
Antigens, Bacterial
Multidisciplinary
Sequence Homology, Amino Acid
Ehrlichiosis
Genetic Variation
Biological Sciences
medicine.disease
biology.organism_classification
bacterial infections and mycoses
Virology
Tick-Borne Diseases
Anaplasmosis
Genome, Bacterial
Pseudogenes
Bacterial Outer Membrane Proteins
Subjects
Details
- ISSN :
- 00278424
- Volume :
- 98
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....b852cdc189baff4d61d505c8d2a71fb8