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Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13
- Source :
- Genomics. 26:443-450
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- The intracellular pathogen Legionella pneumophila is unable to replicate in macrophages derived from most inbred mouse strains. Here, we report the mapping of a gene, called Lgn1, that determines whether mouse macrophages are permissive for the intracellular replication of L. pneumophila. Although Lgn1 has been previously reported to map to mouse chromosome 15, we show here that it actually maps to chromosome 13, between D13Mit128 and D13Mit70. In the absence of any regional candidates for Lgn1, this map position will facilitate positional cloning attempts directed at this gene.
- Subjects :
- Male
Positional cloning
Bone Marrow Cells
Mice, Inbred Strains
Molecular cloning
Legionella pneumophila
Mice
Chromosome 15
Gene mapping
Bone Marrow
Genetics
Animals
Genetic Predisposition to Disease
Cloning, Molecular
Gene
Cells, Cultured
Crosses, Genetic
Chromosome 13
biology
Macrophages
Chromosome Mapping
biology.organism_classification
Female
Legionnaires' Disease
Intracellular
Subjects
Details
- ISSN :
- 08887543
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Genomics
- Accession number :
- edsair.doi.dedup.....b846d62cf7aa9060c397d7b5e7166d6c