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Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition
- Source :
- Beilstein Journal of Nanotechnology, Vol 10, Iss 1, Pp 399-411 (2019), Beilstein Journal of Nanotechnology
- Publication Year :
- 2019
- Publisher :
- Beilstein Institut, 2019.
-
Abstract
- We have constructed thin films of organic–inorganic hybrid character by combining titanium tetra-isopropoxide (TTIP) and the nucleobases thymine, uracil or adenine using the molecular layer deposition (MLD) approach. Such materials have potential as bioactive coatings, and the bioactivity of these films is described in our recent work [Momtazi, L.; Dartt, D. A.; Nilsen, O.; Eidet, J. R. J. Biomed. Mater. Res., Part A 2018, 106, 3090–3098. doi:10.1002/jbm.a.36499]. The growth was followed by in situ quartz crystal microbalance (QCM) measurements and all systems exhibited atomic layer deposition (ALD) type of growth. The adenine system has an ALD temperature window between 250 and 300 °C, while an overall reduction in growth rate with increasing temperature was observed for the uracil and thymine systems. The bonding modes of the films have been further characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and X-ray diffraction, confirming the hybrid nature of the as-deposited films with an amorphous structure where partial inclusion of the TTIP molecule occurs during growth. The films are highly hydrophilic, while the nucleobases do leach in water providing an amorphous structure mainly of TiO2 with reduced density and index of refraction.
- Subjects :
- Materials science
General Physics and Astronomy
02 engineering and technology
lcsh:Chemical technology
010402 general chemistry
lcsh:Technology
01 natural sciences
Full Research Paper
chemistry.chemical_compound
Atomic layer deposition
hybrid materials
Nanotechnology
lcsh:TP1-1185
General Materials Science
Electrical and Electronic Engineering
Fourier transform infrared spectroscopy
Thin film
lcsh:Science
lcsh:T
bioactive materials
Quartz crystal microbalance
nucleobases
021001 nanoscience & nanotechnology
lcsh:QC1-999
0104 chemical sciences
Thymine
Amorphous solid
Nanoscience
chemistry
Chemical engineering
ALD
MLD
lcsh:Q
0210 nano-technology
Hybrid material
Layer (electronics)
lcsh:Physics
Subjects
Details
- ISSN :
- 21904286
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Nanotechnology
- Accession number :
- edsair.doi.dedup.....b83dfce1d0eaa509c3f3371fb5fdc6ed