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Estimating tubular damage for predicting progression of chronic kidney disease—what are the implications for clinical practice and public health?
- Source :
- Nephrol Dial Transplant, Nephrology Dialysis Transplantation
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- BACKGROUND: Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population. METHODS: Subjects without CKD or diabetes were recruited from the general population in Tromso, Norway [Renal Iohexol Clearance Survey (RENIS); N = 1249] and Groningen, the Netherlands [Prevention of REnal and Vascular END-stage disease (PREVEND); N = 4534], with a median follow-up of 5.6 and 7.4 years, respectively. GFR was measured by iohexol clearance in the RENIS and estimated using the CKD Epidemiology Collaboration creatinine–cystatin C equation in the PREVEND study. Rapid GFR decline was defined as an annual GFR loss >3.0 mL/min/1.73 m(2) and in sensitivity analyses as subjects with the 10% steepest GFR slope within each cohort. RESULTS: Lower baseline uEGF excretion was associated with rapid GFR loss in both cohorts {RENIS, odds ratio [OR] per 1 μg/mmol lower uEGF 1.42 [95% confidence interval (CI) 1.06–1.91], P = 0.02; PREVEND, OR 1.29 [95% CI 1.10–1.53], P
- Subjects :
- medicine.medical_specialty
MEDLINE
Kidney
urologic and male genital diseases
Humans
Medicine
Renal Insufficiency, Chronic
AcademicSubjects/MED00340
Intensive care medicine
Netherlands
Transplantation
Epidermal Growth Factor
Norway
business.industry
Public health
Editorials
Klinisk medicin
Original Articles
medicine.disease
female genital diseases and pregnancy complications
Clinical Practice
Kidney Tubules
Nephrology
Creatinine
Disease Progression
Public Health
Clinical Medicine
business
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....b83cd4ea9cfbae8c50c7228daf1f5947