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Supplementary Tables, Figures, References from Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- Supplemental Table 1. AML Patient demographics Supplemental Table 2. MDS Patient demographics Figure S1. ERBB2 is overexpressed and truncated in MDS and AML cells. Figure S2. Lapatinib effectively reduces levels of phospho-ERBB2 in MDS-L and K562 cells. Figure S3. ERBB2 inhibition with Lapatinib impairs MDS and AML cell proliferation. Figure S4. Afatinib and neratinib promotes leukemic cell death. Figure S5. ERBB2 inhibition with Lapatinib decreases MDS xenograft. Figure S6. Inhibition of MCL1 by AZD5991 enhances MDS-L cell death. Figure S7. Dual inhibition of ERBB2 and BCL-2 is synergistic to promote cancer death compared to monotherapy.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b838acd598d051e8ed29eaa8dfdd1edc
- Full Text :
- https://doi.org/10.1158/1541-7786.22526577