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Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
- Source :
- Human molecular genetics. 17(11)
- Publication Year :
- 2008
-
Abstract
- A region along chromosome 7q was recently linked to components of the metabolic syndrome (MetS) in several genome-wide linkage studies. Within this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipoproteins, is a potentially important candidate. CD36 has been documented to play an important role in fatty acid metabolism in vivo and subsequently may be involved in the etiology of the MetS. The protein also impacts survival to malaria and the influence of natural selection has resulted in high CD36 genetic variability in populations of African descent. We evaluated 36 tag SNPs across CD36 in the HyperGen population sample of 2020 African-Americans for impact on the MetS and its quantitative traits. Five SNPs associated with increased odds for the MetS [P = 0.0027-0.03, odds ratio (OR) = 1.3-1.4]. Coding SNP, rs3211938, previously shown to influence malaria susceptibility, is documented to result in CD36 deficiency in a homozygous subject. This SNP conferred protection against the MetS (P = 0.0012, OR = 0.61, 95%CI: 0.46-0.82), increased high-density lipoprotein cholesterol, HDL-C (P = 0.00018) and decreased triglycerides (P = 0.0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes.
- Subjects :
- Adult
CD36 Antigens
Male
medicine.medical_specialty
CD36
Single-nucleotide polymorphism
Type 2 diabetes
Biology
Polymorphism, Single Nucleotide
chemistry.chemical_compound
High-density lipoprotein
Internal medicine
Genetics
medicine
SNP
Humans
Genetic Predisposition to Disease
Molecular Biology
Genetics (clinical)
Metabolic Syndrome
Cholesterol
Cholesterol, HDL
General Medicine
Odds ratio
Articles
Middle Aged
medicine.disease
United States
Black or African American
Endocrinology
chemistry
biology.protein
Female
Metabolic syndrome
Subjects
Details
- ISSN :
- 14602083
- Volume :
- 17
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Human molecular genetics
- Accession number :
- edsair.doi.dedup.....b82f18a04816918799200b931244cd1c