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Alzheimer's disease and immunotherapy: what is wrong with clinical trials?
- Source :
- Immunotargets and Therapy
- Publication Year :
- 2016
-
Abstract
- Alzheimer's disease (AD) is characterized by progressive neurodegeneration and is the most common cause of dementia. Immunotherapy has recently been regarded as a potential treatment for AD. This stems from the fact that the clinical and pathological findings from the active AD vaccine trial suggests that such vaccine therapy may be effective for AD. However, this trial was halted because of the occurrence of meningoencephalitis in some patients. Avoiding excessive immune reaction is necessary for the success of vaccine therapy. For this purpose, adjuvant-free vaccine therapies (eg, passive immunization or DNA vaccines) are currently under investigation. However, the results of clinical trials employing both active and passive anti-amyloid-beta immunotherapy have been unsatisfactory. In this article, we will analyze the reasons for the limited efficacy of currently available immunotherapies and discuss the effectiveness of new vaccine therapies. Finally, we will speculate on the possibility of its clinical application.
- Subjects :
- medicine.medical_specialty
business.industry
medicine.medical_treatment
Immunology
Vaccine trial
amyloid cascade theory
Immunotherapy
Disease
Review
medicine.disease
Vaccine therapy
amyloid-beta
DNA vaccination
Clinical trial
Aβ peptide vaccine
Immunization
monoclonal antibody
medicine
Immunology and Allergy
Dementia
immunotherapy
tau
Intensive care medicine
business
Subjects
Details
- ISSN :
- 22531556
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- ImmunoTargets and therapy
- Accession number :
- edsair.doi.dedup.....b82ef66c5ba800d3d04045d819a6b5b8