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Response to Letters Regarding Article, 'Bacterial Signatures in Thrombus Aspirates of Patients With Myocardial Infarction'
Response to Letters Regarding Article, 'Bacterial Signatures in Thrombus Aspirates of Patients With Myocardial Infarction'
- Source :
- Circulation, Circulation; Vol 128
- Publication Year :
- 2013
-
Abstract
- We thank the authors of the letters for their interest in our publication.1 Their comments focused on Chlamydia pneumoniae –negative finding, role of infection burden and coexistence of multiple pathogens, clinical usefulness of findings, and how the chronic oral infection is involved in acute coronary events. For the last 2 decades, C pneumoniae has been the strongest candidate bacteria behind atherosclerotic inflammation. According to the recent review by Joshi et al,2 there are a total of 1652 published articles on this subject, and various techniques (immunocytochemistry, polymerase chain reaction [PCR], in situ hybridization, electron microscopy, and culturing) have been used to determine the presence of C pneumoniae in vascular tissues. The range of C pneumoniae –positive patients varies greatly across studies from 0% to 100%. Apfalter et al3 reported that 89% of all patients studied had C pneumoniae –specific antibodies, but the pathogen was not detected in a single carotid atheroma by real-time PCR and cell culture in carotid endarterectomy samples. So …
- Subjects :
- Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Immunocytochemistry
Myocardial Infarction
Inflammation
Carotid endarterectomy
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
law
Physiology (medical)
medicine
Humans
Myocardial infarction
Thrombus
Pathogen
Polymerase chain reaction
030304 developmental biology
0303 health sciences
Chlamydia
business.industry
Stomatognathic Diseases
Thrombosis
ta3121
medicine.disease
Viridans Streptococci
3. Good health
Immunology
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Mouth Diseases
Subjects
Details
- ISSN :
- 00097322
- Volume :
- 128
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....b82df72dd8547e93bb8bf7a70bbedab4
- Full Text :
- https://doi.org/10.1161/CIRCULATIONAHA.113.004701