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Cognitive Behavioral Therapy for Patients with Social Anxiety Disorder Who Remain Symptomatic following Antidepressant Treatment: A Randomized, Assessor-Blinded, Controlled Trial
- Publication Year :
- 2016
-
Abstract
- Background: Although antidepressants are still a commonly used treatment for social anxiety disorder (SAD), a significant proportion of patients fail to remit following antidepressants. However, no standard approach has been established for managing such patients. This study aimed to examine the effectiveness of cognitive behavioral therapy (CBT) as an adjunct to usual care (UC) compared with UC alone in SAD patients who remain symptomatic following antidepressant treatment. Methods: This was a prospective randomized open-blinded end-point study with two parallel groups (CBT + UC, and UC alone, both for 16 weeks) conducted from June 2012 to March 2014. SAD patients who remain symptomatic following antidepressant treatment were recruited, and a total sample size of 42 was set based on pilot results. Results: Patients were randomly allocated to CBT + UC (n = 21) or UC alone (n = 21). After 16 weeks, adjusted mean reduction in the Liebowitz Social Anxiety Scale from baseline for CBT + UC and UC alone was −40.87 and 0.68, respectively; the between-group difference was −41.55 (−53.68 to −29.42, p < 0.0001). Response rates were 85.7 and 10.0% for CBT + UC and UC alone, respectively (p < 0.0001). The corresponding remission rates were 47.6 and 0.0%, respectively (p = 0.0005). Significant differences were also found in favor of CBT + UC for social anxiety symptoms, depressive symptoms, and functional impairment. Conclusions: Our results suggest that in SAD patients who have been ineffectively treated with antidepressants, CBT is an effective treatment adjunct to UC over 16 weeks in reducing social anxiety and related symptoms.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Severity of Illness Index
behavioral disciplines and activities
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Japan
Randomized controlled trial
law
mental disorders
medicine
Humans
Prospective Studies
030212 general & internal medicine
Psychiatry
Applied Psychology
Psychiatric Status Rating Scales
Cognitive Behavioral Therapy
Social anxiety
Phobia, Social
General Medicine
Antidepressive Agents
030227 psychiatry
Cognitive behavioral therapy
Psychiatry and Mental health
Clinical Psychology
Treatment Outcome
Antidepressant
Female
Psychology
Clinical psychology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b82a74bac703568e6bd6497d9f4e22be