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Dielectric Nanoparticles Coated upon Silver Hollow Nanosphere as an Integrated Design to Reinforce SERS Detection of Trace Ampicillin in Milk Solution
- Source :
- Coatings, Vol 10, Iss 390, p 390 (2020), Coatings, Volume 10, Issue 4
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Surface-enhanced Raman scattering (SERS) technique is competent to trace detection of target species, down to the single molecule level. The detection sensitivity is presumably degraded by the presence of non-specific binding molecules that occupy a SERS-active site (or hot spot) on the substrate surface. In this study, a silver hollow nano-sphere (Ag HNS) with cavity has been particularly designed, followed by depositing dielectric nanoparticles (Di NPs) upon Ag HNS. In the integrated nanostructures, Di NPs/Ag HNS were furthermore confirmed by cutting through the cross sections using the Focused Ion Beam (FIB) technique, which provides the Scanning Electron Microscope (SEM) with Energy-dispersive Spectroscope (EDS) mode for identifying the distribution of Di NPs upon Ag HNS. The results have indicated that Di NPs/Ag HNS exhibits small diameter of cavity, and among Di NPs in this study, Al2O3 with lower dielectric constant provides a much higher SERS enhancement factor (e.g., ~6.2 &times<br />107). In this study, to detect trace amounts (e.g., 0.01 ppm) of Ampicillin in water or milk solution, Al2O3 NPs/Ag HNS was found to be more efficient and less influenced by non-specific binding molecules in milk. A substrate with integrated plasmonic and dielectric components was designed to increase the adsorption of target species and to repulse non-specific binding molecules from SERS-active sites.
- Subjects :
- surface-enhanced Raman scattering
Materials science
Nanostructure
Scanning electron microscope
technology, industry, and agriculture
non-specific binding
Nanoparticle
Substrate (chemistry)
dielectric nanoparticle
Surfaces and Interfaces
Dielectric
Focused ion beam
Surfaces, Coatings and Films
symbols.namesake
Adsorption
Chemical engineering
lcsh:TA1-2040
Materials Chemistry
symbols
ampicillin
lcsh:Engineering (General). Civil engineering (General)
Raman scattering
silver hollow nanosphere
Subjects
Details
- Language :
- English
- ISSN :
- 20796412
- Volume :
- 10
- Issue :
- 390
- Database :
- OpenAIRE
- Journal :
- Coatings
- Accession number :
- edsair.doi.dedup.....b8254d423651460c40375e04b8e7b44b