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Nelson's syndrome following partial pituitary microadenomectomy and pregnancy
- Source :
- Clinical endocrinology. 36(4)
- Publication Year :
- 1992
-
Abstract
- We report for the first time the development of Nelson's syndrome in a patient who had previously undergone unsuccessful pituitary microadenomectomy and subsequently bilateral adrenalectomy. The removal of a 3-mm portion of a microadenoma did not protect against the development of Nelson's syndrome within 3 years which was closely related to pregnancy, a previously noted association. This report suggests that the development of Nelson's syndrome depends not on the size of the initial pituitary tumour but rather on its individual potential for proliferating once free of the inhibitory effects of glucocorticoid excess.
- Subjects :
- Adult
medicine.medical_specialty
Hypophysectomy
endocrine system diseases
Adenoma
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Pituitary neoplasm
Nelson Syndrome
Cushing syndrome
Endocrinology
Pregnancy
Internal medicine
medicine
Humans
Pituitary Neoplasms
Adenoma, Chromophobe
business.industry
Adrenalectomy
digestive, oral, and skin physiology
Nelson's syndrome
medicine.disease
Female
business
Tomography, X-Ray Computed
Pregnancy Complications, Neoplastic
Subjects
Details
- ISSN :
- 03000664
- Volume :
- 36
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinology
- Accession number :
- edsair.doi.dedup.....b823d9144f08aaf1c58fd51cd652d415