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How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020
- Source :
- Trouillas, J, Jaffrain-Rea, M-L, Vasiljevic, A, Raverot, G, Roncaroli, F & C, C V 2020, ' How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020 ', Cancers, vol. 12, no. 2 . https://doi.org/10.3390/cancers12020514, Cancers, Cancers, Vol 12, Iss 2, p 514 (2020)
- Publication Year :
- 2020
-
Abstract
- Adenohypophyseal tumors, which were recently renamed pituitary neuroendocrine tumors (PitNET), are mostly benign, but may present various behaviors: invasive, “aggressive” and malignant with metastases. They are classified into seven morphofunctional types and three lineages: lactotroph, somatotroph and thyrotroph (PIT1 lineage), corticotroph (TPIT lineage) or gonadotroph (SF1 lineage), null cell or immunonegative tumor and plurihormonal tumors. The WHO 2017 classification suggested that subtypes, such as male lactotroph, silent corticotroph and Crooke cell, sparsely granulated somatotroph, and silent plurihormonal PIT1 positive tumors, should be considered as “high risk” tumors. However, the prognostic impact of these subtypes and of each morphologic type remains controversial. In contrast, the French five-tiered classification, taking into account the invasion, the immuno-histochemical (IHC) type, and the proliferative markers (Ki-67 index, mitotic count, p53 positivity), has a prognostic value validated by statistical analysis in 4 independent cohorts. A standardized report for the diagnosis of pituitary tumors, integrating all these parameters, has been proposed by the European Pituitary Pathology Group (EPPG). In 2020, the pituitary pathologist must be considered as a member of the multidisciplinary pituitary team. The pathological diagnosis may help the clinician to adapt the post-operative management, including appropriate follow-up and early recognition and treatment of potentially aggressive forms.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
endocrine system
Somatotropic cell
pituitary adenoma
030209 endocrinology & metabolism
Review
classification of pituitary tumors
Neuroendocrine tumors
pituitary tumor
lcsh:RC254-282
Prolactin cell
03 medical and health sciences
0302 clinical medicine
Pituitary adenoma
Null cell
medicine
business.industry
Pituitary tumors
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
classification of pituitary neuroendocrine tumors
Oncology
030220 oncology & carcinogenesis
Immunohistochemistry
Corticotropic cell
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Trouillas, J, Jaffrain-Rea, M-L, Vasiljevic, A, Raverot, G, Roncaroli, F & C, C V 2020, ' How to Classify the Pituitary Neuroendocrine Tumors (PitNET)s in 2020 ', Cancers, vol. 12, no. 2 . https://doi.org/10.3390/cancers12020514, Cancers, Cancers, Vol 12, Iss 2, p 514 (2020)
- Accession number :
- edsair.doi.dedup.....b82130852f1b8b62e096ccd6a2935ca1
- Full Text :
- https://doi.org/10.3390/cancers12020514