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Exhaled nitric oxide - circadian variations in healthy subjects
- Source :
- European Journal of Medical Research, Vol 14, Iss Suppl 4, Pp 6-8 (2009), European Journal of Medical Research
- Publication Year :
- 2009
- Publisher :
- BMC, 2009.
-
Abstract
- Objective Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. The level of eNO is influenced by many various factor including age, sex, menstrual cycle, exercise, food, drugs, etc. The aim of our study was to investigate a potential influence of circadian variation on eNO level in healthy subjects. Methods Measurements were performed in 44 women and 10 men, non-smokers, without respiratory tract infection in last 2 weeks. The eNO was detected at 4-hour intervals from 6 a.m. to 10 p.m. using an NIOX analyzer. We followed the ATS/ERS guidelines for eNO measurement and analysis. Results Peak of eNO levels were observed at 10 a.m. (11.1 ± 7.2 ppb), the lowest value was detected at 10 p.m. (10.0 ± 5.8 ppb). The difference was statistically significant (paired t-test, P < 0.001). Conclusions The daily variations in eNO, with the peak in the morning hours, could be of importance in clinical practice regarding the choice of optimal time for monitoring eNO in patients with respiratory disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
media_common.quotation_subject
lcsh:Medicine
Nitric Oxide
Nitric oxide
chemistry.chemical_compound
Internal medicine
Medicine
Humans
Circadian rhythm
Menstrual cycle
media_common
business.industry
Research
lcsh:R
Healthy subjects
General Medicine
circadian variation
Circadian Rhythm
Endocrinology
chemistry
Breath Tests
Medicine public health
Exhaled nitric oxide
exhaled nitric oxide
Female
business
Subjects
Details
- Language :
- English
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- European Journal of Medical Research
- Accession number :
- edsair.doi.dedup.....b81e7f6f64d3c78409be0001b9980c92