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The importance of identifying functional Val158Met polymorphism in catechol-O- Methyltransferase when assessing MRI-based volumetric measurements in major depressive disorder
- Source :
- Brain imaging and behavior. 14(6)
- Publication Year :
- 2020
-
Abstract
- Many studies have shown volumetric differences in the hippocampus between COMT gene polymorphisms and other studies have shown differences between depressed patients and controls; yet, few studies have been completed to identify the volumetric differences when taking both factors into consideration. Using voxel-based morphology (VBM) we investigated, in major depressive disorder (MDD) patients and healthy controls, the relationship between COMT gene polymorphism and volumetric abnormalities. Data from 60 MDD patients and 25 healthy controls were included in this study. Volumetric measurements and genotyping of COMTval158met polymorphism were conducted to determine its impact on gray matter volume (GMV) in the hippocampus and amygdala using a Met dominant model (Val/Val vs Met/Val & Met/Met). In the analysis, a significant difference in the right hippocampus (p = 0.015), right amygdala (p = 0.003) and entire amygdala (p = 0.019) was found between the interaction of diagnosis and genotype after MRI scanner, age and sex correction. Healthy controls (HC) with the Met dominant genotype exhibited a larger right hippocampal, right amygdalar and entire amydgalar volume than MDD patients with the Met dominant genotype. Conversely, HC with the Val/Val genotype displayed a lower right hippocampal, right amygdalar and entire amygdalar volume than their MDD counterparts. This study shows that COMT polymorphism and depression may have a confounding effect on neuroimaging studies.
- Subjects :
- medicine.medical_specialty
Genotype
Cognitive Neuroscience
Catechols
Catechol O-Methyltransferase
behavioral disciplines and activities
Amygdala
050105 experimental psychology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
0302 clinical medicine
Neuroimaging
Polymorphism (computer science)
Internal medicine
mental disorders
medicine
Hippocampus (mythology)
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Depressive Disorder, Major
Catechol-O-methyl transferase
Polymorphism, Genetic
business.industry
05 social sciences
Brain morphometry
Brain
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
Endocrinology
medicine.anatomical_structure
nervous system
Neurology
Major depressive disorder
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19317565
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain imaging and behavior
- Accession number :
- edsair.doi.dedup.....b7fefe312a6d76647495c6fb8b66db03