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Characterization of the contribution of buccal absorption to internal exposure to bisphenol A through the diet
- Source :
- Food and Chemical Toxicology, Food and Chemical Toxicology, Elsevier, 2016, 93, pp.82-88. ⟨10.1016/j.fct.2016.04.004⟩
- Publication Year :
- 2016
-
Abstract
- International audience; The gavage route is often used for the toxicological evaluation of food contaminants. This route does not take into account absorption of the toxicants through the buccal mucosa, as evidenced in dogs for bisphenol A (BPA). Our goal was to determine the functional significance of buccal BPA absorption during dietary exposure. Four ewes received BPA by nasogastric gavage (100 mg/kg) and through food pellets (10 mg/kg), 13 days apart. The time course of serum concentrations of BPA and its main metabolite BPA-G was submitted to non-compartmental analysis. The dietary route led to 3-fold higher bioavailability as compared to gavage. The ratio of BPA-G to BPA concentrations varied greatly over time after the food administration, but not after gavage, suggesting a delayed metabolism of BPA after dietary exposure. The maximum entrance rate of BPA in the systemic circulation, determined by deconvolution analysis, was much higher after dietary administration than after gavage and a biphasic pattern of BPA entry was observed in 3 of the 4 ewes. Our results evidenced a dual mechanism of BPA absorption (buccal and digestive) after dietary exposure and highlight the necessity to take buccal absorption into account when evaluating food contaminants.
- Subjects :
- 0301 basic medicine
Bisphenol A
endocrine system
Metabolite
bisphenol A
[SDV]Life Sciences [q-bio]
Physiology
Oral Mucosal Absorption
Absorption (skin)
010501 environmental sciences
Toxicology
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Dogs
Pharmacokinetics
Phenols
Animals
food toxicology
Tissue Distribution
Buccal Absorption
pharmacokinetic
Benzhydryl Compounds
0105 earth and related environmental sciences
Sheep
urogenital system
Mouth Mucosa
General Medicine
Buccal administration
Free Radical Scavengers
Bioavailability
Diet
030104 developmental biology
chemistry
hormones, hormone substitutes, and hormone antagonists
Food Science
buccal absorption
Subjects
Details
- ISSN :
- 18736351 and 02786915
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Accession number :
- edsair.doi.dedup.....b7fb005a65c2eee6c4026c88ee51fc79