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Synthesis of Polysubstituted Trifluoromethylpyridines from Trifluoromethyl-α,β-ynones

Authors :
Pengfei Li
Tianyu Yang
Ke-Hu Wang
Yulai Hu
Danfeng Huang
Zhoubin Deng
Yingpeng Su
Source :
The Journal of Organic Chemistry. 85:924-933
Publication Year :
2019
Publisher :
American Chemical Society (ACS), 2019.

Abstract

A novel and efficient method for synthesis of polysubstituted trifluoromethylpyridine derivatives by the Bohlmann-Rahtz heteroannulation reaction is described, which use trifluoromethyl-α,β-ynones as trifluoromethyl building blocks to react with β-enamino esters or β-enamino ketones in the presence of ZnBr

Details

ISSN :
15206904 and 00223263
Volume :
85
Database :
OpenAIRE
Journal :
The Journal of Organic Chemistry
Accession number :
edsair.doi.dedup.....b7eae2ad1c3f3b64533583f6687ebde9
Full Text :
https://doi.org/10.1021/acs.joc.9b02873