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Cognitive interference processing in adults with childhood craniopharyngioma using functional magnetic resonance imaging
- Source :
- Endocrine
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Purpose To assess cognitive interference processing in adults with childhood craniopharyngioma (CP), with and without hypothalamic injury, respectively, in terms of behavioral performance and functional magnetic resonance imaging (fMRI) activity, using the multi-source interference task (MSIT). Methods Twenty-eight CP patients (median age 34.5 [29.0–39.5] years) were investigated at median 20.5 (16.3–28.8) years after treatment with surgical resection and in some cases additional radiotherapy (n = 10) and compared to 29 matched controls (median age 37.0 [32.5–42.0] years). The subjects performed the MSIT during fMRI acquisition and behavioral performance in terms of response times (ms) and accuracy performance (%) were recorded. Results The MSIT activated the cingulo-fronto-parietal (CFP) attention network in both CP patients and controls. No differences were found in behavioral performance nor fMRI activity between CP patients (interference effect 333.9 [287.3–367.1] ms and 3.1 [1.6–5.6]%, respectively) and controls (309.1 [276.4–361.0] ms and 2.6 [1.6–4.9]%). No differences were found in behavioral performance nor fMRI activity between the two subgroups with (332.0 [283.6–353.4] ms and 4.2 [2.3–5.7]%, respectively) and without hypothalamic injury (355.7 [293.7–388.7] ms and 2.1 [1.0–5.2]%, respectively), respectively, and controls. Conclusion Adults with childhood CP performed cognitive interference processing equally well as controls and demonstrated no compensatory fMRI activity in the CFP attention network compared to controls. This was also true for the two subgroups with and without hypothalamic injury. The results can be useful to better characterize this condition, and to optimize treatment and support for these individuals.
- Subjects :
- Surgical resection
Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Hypothalamic injury
Audiology
03 medical and health sciences
Craniopharyngioma
0302 clinical medicine
Endocrinology
Cognition
Attention network
Multi-source interference task
medicine
Reaction Time
Humans
Pituitary Neoplasms
Child
medicine.diagnostic_test
business.industry
fMRI
Childhood Craniopharyngioma
Cognitive interference
medicine.disease
Magnetic Resonance Imaging
Original Article
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
After treatment
Subjects
Details
- Language :
- English
- ISSN :
- 15590100 and 1355008X
- Volume :
- 74
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....b7dead5868b7f01722bb10606df0dd20