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Erythropoietin Dampens Injury-Induced Microglial Motility
- Source :
- Journal of Cerebral Blood Flow and Metabolism, Journal of Cerebral Blood Flow & Metabolism
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.
- Subjects :
- Traumatic brain injury
medicine.medical_treatment
Motility
Biology
Brief Communication
migration
Neuroprotection
Cell Movement
medicine
Humans
Cognitive decline
Erythropoietin
Cells, Cultured
Microglia
Growth factor
Neurodegeneration
ATP
brain injury
process protrusion
Rac1
medicine.disease
Recombinant Proteins
3. Good health
Neuroprotective Agents
medicine.anatomical_structure
Neurology
Brain Injuries
Cancer research
Neurology (clinical)
Cardiology and Cardiovascular Medicine
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 15597016 and 0271678X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....b7dcb13b6f60813f566e15ffaa12588d