HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON

Serological studies on the immunogenic properties of biphenyl bridge conjugates of paralytic shellfish poison and protein (PSP-azo-biphenyl- azoovalbumin) indicate that antibodies produced by rabbits were directed against the protein portion of the molecule and that the PSP moiety did not possess haptenic properties. A method of coupling PSP to protein in an acid media through the intermediate action of formaldehyde is also described. Evidence is presented which suggests that the PSP is only slightly altered in this synthesis.