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Cutting Edge: Chemoprevention of Colorectal Neoplasia in Inflammatory Bowel Disease
- Source :
- Inflammation & Allergy-Drug Targets. 12:1-7
- Publication Year :
- 2013
- Publisher :
- Bentham Science Publishers Ltd., 2013.
-
Abstract
- Colitis-associated cancer represents a long-standing problem, with two new factors adding to its importance: the diffusion of inflammatory bowel disease in developing countries, and the increased availability of effective drugs that control ulcerative colitis delaying or abrogating the need for a curative colectomy. The consolidated evidence that inflammation is the unique variable that factors in colitic cancer development has conferred impetus to the search and release of anti-inflammatory/immune suppressive molecules to pursue the goal of cancer chemoprevention. Cutting-edge research has provided breakthrough insights into the mechanism of the chemopreventive actions of mesalamines, thiopurines, and probiotics, and we expand on these topics. Despite these advancements, bedside evidence is still mixed and calls for further scrutiny. Nowadays, the clinician must continue to rely on classic preventive measures such as surveillance colonoscopy, and the early and aggressive use of drugs that permit to keep the degree of mucosal inflammation to a minimum.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Immunology
Anti-Inflammatory Agents
Colonoscopy
Inflammation
Chemoprevention
Inflammatory bowel disease
Gastroenterology
inflammatory bowel disease
ulcerative colitis
colorectal neoplasia
thiopurines
probiotics
mesalamines
Immune system
Internal medicine
medicine
Animals
Humans
Immunology and Allergy
Mesalamine
Thioguanine
Intensive care medicine
Colectomy
Pharmacology
medicine.diagnostic_test
business.industry
Mechanism (biology)
Cancer
General Medicine
Inflammatory Bowel Diseases
medicine.disease
Ulcerative colitis
Cell Transformation, Neoplastic
medicine.symptom
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 18715281
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Inflammation & Allergy-Drug Targets
- Accession number :
- edsair.doi.dedup.....b7d4ac532a937b64e94a47a8fbd15069