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The distribution of glutathione in the rat liver lobule
- Source :
- The Biochemical journal. 182(1)
- Publication Year :
- 1979
-
Abstract
- A quantitative cytochemical method was developed for measuring the GSH (reduced glutathione) content of hepatocytes in different regions of the rat liver lobule. Use of this method enabled us to show that GSH is not evenly distributed within the rat liver lobule. The hepatocytes located within 100 micrometer of the central vein contain much less GSH than do those in other regions of the rat liver lobule. We suggest that this partially explains the peculiar susceptibility of these cells to electrophilic attack by toxic metabolites formed via the microsomal cytochrome P-450 system.
- Subjects :
- Male
Cytochrome
biology
Maleates
Cell Biology
Glutathione
Ascorbic Acid
Biochemistry
Rats
chemistry.chemical_compound
chemistry
Liver
Rat liver
biology.protein
Microsome
Methods
Distribution (pharmacology)
Animals
Sulfhydryl Compounds
Molecular Biology
Densitometry
Prussian Blue Reaction
Research Article
Subjects
Details
- ISSN :
- 02646021
- Volume :
- 182
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Biochemical journal
- Accession number :
- edsair.doi.dedup.....b7d479f1cf409f093bfa21335e02e782