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Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review
- Source :
- International Journal of Hyperthermia, International Journal of Hyperthermia, Taylor & Francis, 2014, 30 (7), pp.513-523. ⟨10.3109/02656736.2014.971446⟩
- Publication Year :
- 2014
-
Abstract
- International audience; In recent years there has been enormous interest in researching oxidative stress. Reactive oxygen species (ROS) are derived from the metabolism of oxygen as by-products of cell respiration, and are continuously produced in all aerobic organisms. Oxidative stress occurs as a consequence of an imbalance between ROS production and the available antioxidant defence against them. Nowadays, a variety of diseases and degenerative processes such as cancer, Alzheimer’s and autoimmune diseases are mediated by oxidative stress. Heat stress was suggested to be an environmental factor responsible for stimulating ROS production because of similarities in responses observed following heat stress compared with that occurring following exposure to oxidative stress. This manuscript describes the main mitochondrial sources of ROS and the antioxidant defences involved to prevent oxidative damage in all the mitochondrial compartments. It also deals with discussions concerning the cytotoxic effect of heat stress, mitochondrial heat-induced alterations, as well as heat shock protein (HSP) expression as a defence mechanism.
- Subjects :
- Cancer Research
Antioxidant
MESH: Oxidative Stress
Physiology
Cellular respiration
medicine.medical_treatment
Apoptosis
Oxidative phosphorylation
Mitochondrion
Biology
medicine.disease_cause
reactive oxygen species (ROS)
DNA, Mitochondrial
MESH: Lipid Peroxidation
heat stress
Electron Transport
Physiology (medical)
medicine
Humans
MESH: Electron Transport
chemistry.chemical_classification
MESH: DNA Damage
Reactive oxygen species
MESH: Humans
MESH: Apoptosis
MESH: DNA, Mitochondrial
Metabolism
MESH: Heat-Shock Response
mitochondria
Oxidative Stress
chemistry
Biochemistry
MESH: Reactive Oxygen Species/metabolism
Lipid Peroxidation
Reactive Oxygen Species
Oxidative stress
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Heat-Shock Response
DNA Damage
Subjects
Details
- ISSN :
- 14645157 and 02656736
- Volume :
- 30
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
- Accession number :
- edsair.doi.dedup.....b7cb99ba4936d20993d9e0929962c604